奥美拉唑联合血凝酶对胃溃疡伴上消化道出血的疗效

摘要

Objective To explore the effects of omeprazole combined with hemocoagulase in the treatment of gastric ulcer complicated with upper gastrointestinal bleeding(UGB).Methods A total of 89 patients with gastric ulcer complicated with UGB were selected and randomlv divided into a control group(n=45) and an observation group (n=44).On the basis of conventional treatment,the control group was additionally treated with omeprazole and the observation group with omeprazole combined with hemocoagulase.The levels of vascular endothelial growth factor (VEGF),epidermal growth factor (EGF),superoxide dismutase (SOD) and tumor necrosis factor-α (TNF-α) before and after the treatment and bleeding during treatment,ulcer healing and adverse reactions between the two groups were compared.Results After three-day treatment,the EGF,VEGF,TNF-α and SOD in the two groups were greatly improved (P ＜ 0.05),and the VEGF,EGF and SOD in the observation group were significantly higher than those in the control group and TNF-α was much lower than that in the control group (P ＜ 0.05);the mean hemostatic time in the observation group was much shorter than that in the control group (P ＜ 0.05),and the total healing rate of lesions in the observation group (93.2％) was much higher than that in the control group (82.2％)(P ＜ 0.05);during the treatment,there was no difference between the incidence of adverse reactions in the observation group (18.2％) and that in the control group (15.6％) (P ＞ 0.05).Conclusion In the treatment of gastric ulcer complicated with UGB,omeprazole combined with hemocoagulase can better improve the serum cytokine balance of patients,promote the healing of lesions,and has better hemostatic effects than the treatment only with omeprazole.%目的 探究奥美拉唑联合血凝酶对胃溃疡伴上消化道出血患者的临床疗效.方法 收集胃溃疡伴上消化道出血患者89例,随机分对照组和观察组,分别为45例和44例.在常规治疗基础上,对照组予以奥美拉唑治疗,观察组给予奥美拉唑联合血凝酶治疗.比较两组治疗前后血管内皮生长因子(VEGF)、表皮生长因子(EGF)、超氧化物歧化酶(SOD)及肿瘤坏死因子-α (TNF-α)水平,以及治疗中出血情况、溃疡病灶愈合及不良反应发生情况.结果 经过3d治疗,两组的EGF、VEGF、TNF-α及SOD均有较好改善(P＜0.05),且观察组的VEGF、EGF、SOD显著高于对照组,TNF-α明显小于对照组(P＜0.05);观察组平均止血时间明显少于对照组(P＜0.05),观察组总病灶愈合率(93.2％)显著高于对照组(82.2％)(P＜0.05);治疗期间,观察组不良反应发生率(18.2％)与对照组(15.6％)无统计学差异(P＞0.05).结论 相较于奥美拉唑单药治疗,奥美拉唑联合血凝酶治疗胃溃疡伴上消化道出血,可更有效改善患者的血清细胞因子平衡,促进病灶愈合,止血效果更好.