前列腺癌患者骨转移相关危险因素分析

摘要

Objective:To analyze and investigate risk factors associated with prostate cancer with bone metastasis by gathering general information of newly diagnosed prostate cancer patients with bone metastases. Methods:120 cases with prostate cancer were selected and divided into observation group ( with bone metastases) and control group ( without bone metastases) according to bone me-tastases or not, 60 cases in each group. The Logistic regression univariate and multivariate analysis were used. Results:The capsule infiltration, pelvic lymph node hyperplasia, age, PSA value and Gleason score of observation group were significantly higher than those of control group. The age (OR=1. 301), PSA value (OR=1. 218), Gleason score (OR=7. 026), capsular infiltration (OR=333. 987) were the main risk factor for bone metastasis of the patients with prostate cancer. Conclusions: The high-risk factors for bone metastasis of prostate cancer are age, PSA, Gleason score and capsule infiltration.%目的：：搜集初诊前列腺癌骨转移患者的一般资料，分析研究前列腺癌骨转移的相关危险因素。方法：选取前列腺癌患者120例，按照是否骨转移分为观察组和对照组，每组各60例。观察组患者为骨转移者；对照组患者为无骨转移者。采用Logistic回归方法对两组患者进行单因素和多因素分析。结果：观察组患者包膜浸润、盆腔淋巴结增生、年龄、PSA 值、Gleason 评分均显著高于对照组。年龄( OR=1.301)、PSA 值(OR=1.218)、Gleason 评分(OR=7.026)、有无包膜浸润(OR=333.987)为前列腺癌患者发生骨转移的主要危险因素。结论：前列腺癌患者骨转移的高危因素为年龄、PSA、Gleason 评分和包膜浸润。