Objective To study the safety and effectiveness of nitrous oxide ( ≤70% ) for colonoscopy. Methods A total of 630 patients who underwent colonoscopy from April 2011 to December 2011 were divided into group A (nitrous oxide - colonoscopy group, n=330) and group B (conventional colonoscopy group, n =300). Their heart rate (HR) , oxygen saturation and sedative effects were compared. Results The perioperative reaction in group A was obviously lower than in group B. In group A, the perioper-ative HR was obviously lower than the preoperative HR [ (74. 90 ± 13. 65 )vs (79. 16 ± 14. 67) ,P <0. 05] and the perioperative SpO2 was significantly higher than the preoperative SpO2[ (99. 64 ±1. 04)% ws(99. 14±1.35)%,P<0.05]. In group B, the perioperative HR was significantly higher than the preoperative HR(89. 80 ± 13. 52) vs (79.77 ± 13. 35) ,P <0.05] and the perioperative SpO2 was slightly higher than the preoperative SpO2[ (99. 64 ± 1. 04) % vs(99. 14 ± 1. 35) % ,P <0.05] ,but the difference was not statistically significant. Conclusions Nitrous oxide for colonoscopy is comfortable, safe and feasible.%目的 研究笑气(N2O)清醒镇静在肠镜检查中的安全性和有效性.方法 将 2011-04至2011-12在我院行笑气清醒镇静肠镜检查的330例患者作为A组,同期常规肠镜检查300例患者作为B组,对其HR、SpO2、反应情况及镇静效果等进行研究分析.结果 A组术中不适反应明显低于B组.A组中,术中HR低于术前[(74.90±13.65)次/min vs (79.16±14.67)次/min,P＜0.05],但术中HR在正常安全范围内;术中SpO2高于与术前[99.64±1.04)% vs (99.14±1.35)%,P＜0.05].B组中,术中HR高于术前[(89.80±13.52) vs (79.77±13.35),P＜0.05];术中SpO2稍低于与术前[(99.42±1.07)% vs (99.53±1.12)%],但差异无统计学意义.结论 笑气清醒镇静肠镜检查提高了肠镜检查的舒适度,安全、可行.
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