微量射频技术治疗胃食管反流病5年随访研究

摘要

目的 随访研究内镜下微量射频技术治疗胃食管反流病的5年疗效. 方法 对接受微量射频治疗的难治性胃食管反流病患者进行随访研究,选择治疗前、治疗后1年、治疗后5年三个时间点,对胃食管反流症状积分( GERD-HRQL)、症状控制满意度、药物使用情况进行临床观察. 结果 微量射频治疗后患者胃食管反流症状发作明显减轻,GERD-HRQL积分由治疗前的25.6 ±9.0,降至8.7 ±3.4(治疗后5年,P<0.01);烧心积分由治疗前的3.3 ±1.3,降至1.3 ±1.0(治疗后5年, P<0.05);患者对症状控制满意率由治疗前的31.1%升至71.6%,满意度积分由治疗前的1.4升至3.8(P<0.01). 治疗前全部患者需要使用质子泵抑制药(PPI)PPI控制症状,治疗后5年,70.1%患者不需要服用PPI. 结论 微量射频治疗技术可以显著改善胃食管反流症状、提高患者对治疗的满意度、显著减少PPI的用量,是治疗难治性胃食管反流病的有效方法.%Objective To evaluate the symptom control and medication changes after the Stretta procedure with gastroesopha -geal reflux disease (GERD) during a 5-year follow-up period.Methods We evaluated GERD-health-related quality of life, satisfaction and medication use at baseline and 12 and 60 months after treatment.Results Significant changes in symptoms of GERD, the mean GERD -HRQL score was 25.6 (baseline),and 8.7(60 months,P <0.01).The mean heartburn score was 3.3 (baseline),and 1.3(60 months,P <0.05).The percentage of patients with satisfactory GERD control improved from 31.1% at baseline to 71.6% after treatment, and patient satisfaction improved from 1.4 at baseline to 3.8 at 60 months (P <0.01).Medication usage decreased significantly from 100% of patients on PPI therapy at baseline to 70.1% at 60 months.Conclusions The experience with Stretta procedure confirms that it is well tolerated, safe, effective, and durable in the treatment of GERD.It produces significant improvements in symptom control and and dec reased medication usage during a 5-year period follow-up.