MTSS1和Gli1蛋白在子宫内膜腺癌组织中的表达及意义

摘要

ObjectiveTo investigate the expression and clinical significance of MTSS1 and Gli1 protein in endometrial adenocarcinoma.Methods36 cases of endometrial adenocarcinoma were selected as research group and 36 cases endometrial tissue samples with uterine leiomyoma was selected as control group. These cases were all admitted in the department of obstetrics and gynecology of our hospital from May 2010 to July 2015. Immunohistochemistry was used to test the expression of MTSS1 and Gli1 protein in the two groups.ResultsThe MTSS1 protein expression rate in the study group was significantly lower than the control group with uterine leiomyoma endometrial tissue (P<0.05),but the Gli1 protein expression rate in the study group was significantly higher(P<0.05).ConclusionThe low expression rate of MTSS1 protein and the high expression rate of Gli1 in endometrial adenocarcinoma are related to the development of endometrial cancer diseases. Testing the MTSS1 and Gli1 protein may provide a reference for clinical prevention and diagnosis of endometrial adenocarcinoma.%目的：探讨MTSS1和Gli1蛋白在子宫内膜腺癌组织中的表达及临床意义。方法选取2010年5月—2015年7月我院妇产科收治的36例子宫内膜腺癌患者的病变内膜组织作为研究组，同时选取36例因子宫平滑肌瘤行全子宫切除术的患者的子宫内膜组织作为对照组，采用免疫组化法检测2组研究样本中MTSS1和Gli1蛋白的阳性表达情况。结果研究组患者的病变组织中MTSS1蛋白阳性表达率明显低于对照组患者子宫内膜组织（P＜0.05）；Gli1蛋白阳性表达率明显高于对照组患者子宫内膜组织（P＜0.05）。结论 MTSS1蛋白在子宫内膜腺癌组织中低表达，Gli1蛋白在子宫内膜腺癌组织中高表达，两种蛋白可能与子宫内膜癌的发生、发展存在密切关系，有可能成为子宫内膜腺癌诊断及病情监测的辅助参考指标。