氟伐他汀缓释片联合氯吡格雷治疗不稳定型心绞痛疗效观察

摘要

Objective:To observe the therapeutic effects of combined fluvastatin-clopidogrel treatment on unstable angina pectoris(UAP). Method:58 patients with UAP treated in our hospital from April 2010 to December 2012 were selected and randomly divided into control group and treatment group according to random number table method,each had 29 patients. Conventional treatment was given in the control group,while fluvastatin sustained-release tablets combined with clopidogrel was used in the treatment group on the basis of conventional treatment for four weeks. Compared the index of serum total cholesterol(TC),triglycerides(TG),low-density lipoprotein(LDL-C),high-density lipoprotein(HDL-C),high-sensitivity C-reactive protein(hs-CRP)between two groups. Observed their clinical effects and side effect. Result:After treatment,all the index of TC,TG, LDL-C,HDL-C and hs-CRP were better in both of groups(P<0.05),while the index of TC,TG,LDL-C,HDL-C and hs-CRP of treatment group were better than those of control group(P<0.05). The clinical total effective rate of the treatment group was 93.10%,which was better than 68.97%of control group(P<0.05). There were no side effects in both of groups. Conclusion:Fluvastatin sustained-release tablets combined with clopidogrel shows efficacy on treating UAP,significantly improve the clinic index of patients. Thus,the treatment method is safe and reliable,and worth to popularize.%目的：观察氟伐他汀缓释片联合氯吡格雷治疗不稳定型心绞痛（UAP）的疗效。方法：选择2010年4月-2012年12月本院治疗的UAP患者58例，按随机数字表法分为治疗组和对照组各29例。对照组给予常规治疗，治疗组在常规治疗的基础上再给予氟伐他汀缓释片联合氯吡格雷治疗，两组均治疗4周。比较两组患者治疗前后血清总胆固醇（TC）、甘油三脂（TG）、低密度脂蛋白（LDL-C）、高密度脂蛋白（HDL-C）、高敏C反应蛋白（hs-CRP）等指标；观察两组临床疗效及不良反应。结果：两组治疗后TC、TG、LDL-C、HDL-C、hs-CRP均优于治疗前（P<0.05），且治疗组治疗后均优于对照组（P<0.05）；治疗组总有效率93.10%优于对照组68.97%（P<0.05）；两组均无明显不良反应。结论：氟伐他汀缓释片联合氟吡格雷治疗UAP疗效确切，能显著改善患者临床指标，安全可靠，值得推广应用。