C反应蛋白在慢性阻塞性肺疾病急性加重期血清中的表达特点及临床意义

摘要

目的：检测并分析COPD患者急性加重期与稳定期C反应蛋白的差别及AECOPD患者治疗前后C反应蛋白的变化，探讨其动态变化的临床价值。方法：选择77例COPD患者，其中29例为稳定期COPD患者，48例为急性加重期COPD患者，检测其在治疗前及使用抗生素后10~14 d的CRP水平，分析这些指标的变化情况，探讨CPR对COPD患者治疗诊断的指导意义。结果：在急性加重期CRP水平较稳定期明显升高，经治疗后迅速下降，其变化差异具有统计学意义（P<0.05）。结论：CRP检测对COPD急性加重期感染的诊断及疗效观察、预后判定具有一定的辅助诊断意义。%Objective:To detect and analyze the difference between COPD patients with acute exacerbation and stability of C-reactive protein and changes in the AECOPD patients with CRP before and after treatment,and to explore the clinical value of dynamic change.Method:77 cases of patients with AECOPD were selected,including 29 cases of patients with stable COPD,48 cases of acute exacerbation of COPD patients.CRP levels before treatment and 10-14 days after the use of antibiotics were tested.The changes in these indicators were analyzed and the significance of the CPR on the treatment of patients with COPD were explored.Result:CRP levels were significantly higher in patients with acute exacerbation of and declined rapidly after treatment,and there was significant difference(P<0.05).Conclusion:Detection of CRP may play an important role in the diagnosis,observation of treatment effect and prognosis.