目的：探讨三维适形放疗同期奈达铂化疗治疗局部晚期鼻咽癌近期疗效，为其临床治疗提供可参考依据。方法：连续收集100例入住本院诊断为局部晚期鼻咽癌患者，采用随机数字法平均分为A、B两组，A组患者给予三维适形放疗同期给予奈达铂化疗治疗措施， B组患者给予三维适形放疗同期给予顺铂化疗治疗措施，观察两组患者的近期临床疗效及相关并发症的发生。结果：A组患者完全缓解、部分缓解例数及总有效率明显高于B组患者，两组间比较差异有统计学意义（P<0.05）。A组患者急性不良反应的发生率26.0%，慢性不良反应的发生率74.0%，B组患者急性不良反应的发生率32.0%，慢性不良反应的发生率76.0%，两组间比较差异无统计学意义（P>0.05）。结论：三维适形放疗对治疗局部晚期鼻咽癌有较好的临床疗效，同时辅以予奈达铂化疗治疗临床疗效更好，且其不良反应的发生率未有明显增加，值得临床推广应用。%Objective:To observe the short-term effect of three-dimensional conformal radiotherapy with concurrent chemotherapy for locally advanced nasopharyngeal carcinoma.Method:Continuously collected 100 cases in our hospital diagnosed with locally advanced nasopharyngeal carcinoma patients with digital method adopted randomly divided into A,B two groups,group A patients were given three-dimensional conformal radiation therapy, at the same time gave nida’s platinum chemotherapy treatment,B group patients were given three-dimensional conformal radiation therapy,at the same time gave cisplatin chemotherapy treatment,observed two groups of patients with recent clinical efficacy and related complications. Result:The cases of complete response,partial response and the total effective rate in group A patients were significantly higher than that of group B patients,total effective rate was 86.0%and 68.0%respectively,comparing difference between the two groups was statistically significant(P<0.05). The incidence of adverse reactions in patients with group A,26.0%chronic adverse reaction rate of 74.0%,the incidence of adverse reactions in patients with group B 32.0%, chronic 76.0%incidence of adverse reactions,there was no statistically significant difference between the two groups(P>0.05).Conclusion:Three-dimensional conformal radiotherapy for locally advanced nasopharyngeal carcinoma has better clinical curative effect,at the same time complementary with chemotherapy treatment clinical curative effect is better,and the incidence of adverse reactions did not significantly increase,it is worthy of clinical popularization and application.
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