目的：通过用替吉奥来治疗老年胃癌患者，观察治疗结果的疗效以及产生的不良反应情况，对患者的满意度进行调查统计。方法：选取入住本院的老年胃癌患者96例，随机分为治疗组和对照组两组，治疗组采用替吉奥胶囊来治疗，对照组采用奥沙利铂联合亚叶酸钙和氟尿嘧啶方案治疗。结果：治疗组总有效率为87.5%，对照组总有效率为72.9%，差异有统计学意义（P<0.05）；两组不良反应情况比较，主要的不良反应体现在肝功能损伤、骨髓抑制、胃肠道反应三个方面，治疗组的患者出现Ⅲ-IV 级毒副作用的有7例（14.5%），而对照组为13例（27.1%），比较差异有统计学意义（P<0.05）。两组治疗满意情况统计显示，治疗组患者的满意度为66.7%，对照组为56.3%，比较差异无统计学意义（P>0.05）。结论：替吉奥用于治疗老年胃癌患者的疗效显著，不良反应少，值得临床推广使用。%Objective:To explore and statistical analysis clinical effects,adverse effects and patient satisfactions in the treatment of elderly patients with gastric cancer by TS-1.Method:96 patients with elderly gastric cancer were randomly divided into two groups.The treatment group were treated with TS-1,the control group were treated with oxaliplatin combined with calcium folinate and fluorouracil.Result:The total effective rate of treatment group and control group were 87.5% and 72.9%,with a statistically significant difference(P<0.05);the adverse reactions in the two groups mainly reflected in hepatic injury,myelosuppression and gastrointestinal infection.Compared to 13 cases(27.1%)in the control group,there were 7 cases(14.5%) appeared Ⅲ -IV grade side effects in the treatment group,which had a significant difference(P<0.05).The satisfaction of treatment group and control group were 66.7% and 56.3% respectively,the treatment satisfaction statistics showed that there were no significant difference(P>0.05).Conclusion:TS-1 has a significant efficacy and few adverse effect for the treatment of elderly patients with gastric cancer,which is worth applying in the clinical.
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