后续经动脉化疗栓塞术介入应用于胆管癌并阻塞性黄疸治疗的临床研究

摘要

目的：探讨后续经动脉化疗栓塞术介入在胆管癌并阻塞性黄疸治疗中的临床价值.方法：选择2009年1月-2010年12月在本院进行治疗的胆管癌并阻塞性黄疸患者中能有效接受随访者为研究对象,共38例,所有入选患者均经病理检查证实.机械抽样随机将其中的11例分为A组,采取常规EMBE介入治疗；余27例分为B组,在常规EMBE介入治疗后加用局部灌注栓塞化疗术.结果：B组术后2 w血清TBIL及DBIL均显著低于A组(P<0.05)；血清STP和A水平显著高于A组(P<0.05)；无进展生存期显著长于A组(P<0.05)；总生存期显著长于A组(P<0.05).结论：对于胆管癌并阻塞性黄疸的患者,EMBE术后加用后续经动脉化疗栓塞术,可显著降低胆红素水平,有效改善肝功能,提高患者生存期.%Objective:To explore clinical effect of follow-up arterial chemoembolization intervention used in bile duct carcinoma and obstructive jaundice treatment.Method:Choosing bile duct carcinoma and obstructive jaundice patients during January 2009-December 2010 who can accept the visitor with effective as the research object,and all patients were confirmed by pathological examination.Mechanical sampling randomly chose one of the 11 cases were divided into group A and take regular EMBE intervention treatment.The 27 patients divided into group B,in conventional EMBE after interventional therapy plus local infusion chemotherapy embolization operation.Result:Postoperative serum TBIL and DBIL of group B patients were significantly lower than in A group of patients(P<0.05);Group B patients postoperative serum STP and A were significantly higher than the level of A group of patients(P<0.05);Progression-free surial for group B patients was significantly longer than A group of patients(P<0.05);Group B patients overall survival was significantly longer A group of patients(P<0.05).Conclusion:For bile duct carcinoma and obstructive jaundice patients,EMBE postoperative plus a follow-up arterial chemoembolization can significantly reduce the bilirubin level and effectively improve the liver function,improve the survival period.