奈达铂腹腔热灌注化疗+LV5-Fu2方案治疗胃肠道癌并癌性腹水的临床观察

摘要

目的：研究晚期胃肠道癌合并癌性腹水病治疗中应用奈达铂（奥先达）腹腔热灌注化疗+LV5-Fu2方案的临床效果及安全性。方法：选取2012年6月-2014年6月在本院接受治疗的32例晚期胃肠道癌合并癌性腹水患者为研究对象，按随机数表法分为对照组与观察组，每组各16例。观察组行奈达铂（奥先达）腹腔热灌注化疗+LV5-Fu2方案治疗，对照组行常规LV5-Fu2方案治疗，观察两组患者的肿瘤病情缓解情况，腹腔积水的消退情况以及不良反应发生情况，比较两组的疗效及不良反应的差异。结果：观察组腹腔积水治疗总有效率87.5%显著高于对照组的50%，差异有统计学意义（P<0.05）；观察组的肿瘤缓解率56.25%显著高于对照组的37.5%，两组差异有统计学意义（P<0.05）；观察组的不良反应发生率为37.5%，对照组为31.25%，差异无统计学意义（P>0.05）。结论：晚期胃肠道癌合并癌性腹水患者应用奈达铂（奥先达）腹腔热灌注化疗+LV5-Fu2方案疗效显著，不良反应发生率与LV5-Fu2方案相当，有临床推广价值。%Objective:To investigate the clinical effect and safety of nedaplatin intraperitoneal hyperthermic perfusion chemotherapy plus LV5-Fu2 in treatment of advanced gastrointestinal carcinoma complicated with ascites. Method:32 patients of advanced gastrointestinal carcinoma complicated with ascites treated in our hospital from June 2012 to June 2014 were selected as the research objects and divided into control group and observation group by a random number table,16 cases in each group.The observation group were treated with nedaplatin(Austrian Xianda)intraperitoneal hyperthermic perfusion chemotherapy plus LV5-Fu2,and the control group were routinely treated with LV5-Fu2.The curative effect and the difference of adverse reaction between the two groups were compared by observing tumor remission status ,the occurence of abdominal seeper subsiding and adverse reaction.Result:The total effective rate of observation group for abdominal dropsy was 87.5%,significantly higher than 50%of the control group,the difference was statistically significant(P<0.05);the tumor remission rate of the observation group was 56.25%,significantly higher than 37.5%of the control group,and the difference between two groups was statistically significant(P<0.05).The incidence of adverse action of the observation group was 37.5%,higher than 31.25%of the control group,but the difference was not statistically significant(P>0.05).Conclusion:The application of nedaplatin(Austrian Xianda)intraperitoneal hyperthermic perfusion chemotherapy plus LV5-Fu2 scheme in patients of advanced gastrointestinal cancer complicated with ascites has marked effect and quite effect with LV5-Fu2 scheme in the rate of adverse reactions,so it has clinical value.