胺碘酮联合美托洛尔在心律失常临床治疗中的应用研究

摘要

目的：探究胺碘酮联合美托洛尔治疗心律失常的临床疗效，为保障临床用药的科学性和安全性提供参考依据。方法：以本院2011年12月-2013年6月收治的147例心律失常患者为研究对象，按随机数字表法分为三组，每组各49例。三组患者均给予常规对症治疗，在此基础上对照组A患者选择单用胺碘酮进行治疗，对照组B患者选择单用美托洛尔进行治疗，观察组患者选择胺碘酮联合美托洛尔进行治疗，观察比较三组的起效时间、窦性心律转复率、有效率、不良反应以及治疗前后三组血压和心率变化情况。结果：观察组的窦性心律转复率为91.84%，有效率为95.92%，对照组A分别为63.27%、71.43%；对照组B分别为67.35%、69.39%，差异均具有统计学意义（P<0.05）；观察组起效时间为（0.4±0.1）h，对照组A为（7.9±0.6）h，对照组B为（8.3±1.2）h，三组比较差异均有统计学意义（P<0.05）；治疗后观察组收缩压、舒张压、心率与治疗前比较差异具有统计学意义（P<0.05），而对照组A、B治疗前后差异无统计学意义（P>0.05）；三组均未出现严重不良反应，比较差异无统计学意义（P>0.05）。结论：对于心率失常患者，胺碘酮联合美托洛尔具有较高临床疗效的同时，安全性也比较高，值得临床上推广应用。%Objective:To investigate the clinical effect of amiodarone combined with metoprolol in the treatment of arrhythmia,and provide reference frame for protecting scientific and security of clinical medication. Method:147 patients with arrhythmia from December of 2011 to June of 2013 in our hospital,were divided into three groups randomly,49 patients in each group. All patients were given conventional treatment. On the basis,patients of the control group A were given amiodarone,and patients of control group B were given metoprolol,and patients of observation group were given amiodarone combined with metoprolol. Onset time,cardioversion rate of heart rate,effective rate and adverse effects rate of three groups were compared and blood pressure and heart rate of three groups also were compared before and after treatment. Result:The cardioversion rate of heart rate and effective rate of the observation group respectively was 91.84%,95.92%,the control group A respectively was 63.27%,71.43%,the control group B respectively was 67.35%,69.39%,and the difference between the observation group and the control group A,B had statistical significance(P<0.05). The onset time of observation group was(0.4±0.1)h,the control group A was(7.9±0.6)h,the control group B was(8.3±1.2)h,and the difference between the observation group and the control group A,B had statistical significance(P<0.05). Before and after treatment, the difference of systolic pressure,diastolic pressure,heart rate of the observation group had statistical significance(P<0.05), and the control group A,B had no statistical significance(P>0.05). There were not severe adverse reactions of three groups and the difference had no statistical significance(P>0.05). Conclusion:For patients with arrhythmia,amiodarone combined with metoprolol has high clinical efficacy,and the safety is also high,worthy of clinical application.