烧伤患者早期合并心肌细胞及心功能损害的临床监测

摘要

Objective:To explore the clinical value of h-FABP and NT-proBNP in monitoring early combined damages of myocardial cells and cardiac function by observing change of serum h-FABP and NT-proBNP level in early burn patients.Method:A total of 49 cases with myocardial cell damage(the damage group)and 50 healthy people(the control group)were selected as the research objects.Serum h-FABP was detected by ELISA one-step,and serum NT-proBNP was inspected by ECLIA method.Result:The positive rate of serum h-FABP in burn patients(80.3%)before the treatment was significantly higher than that of NT-proBNP(50.8%)(P<0.01).The level of serum NT-proBNP and h-FABP in the damage group before treatment were significantly higher than that in the control group(P<0.01),and that of the two groups after treatment were significantly lower than that before treatment(P<0.01),and that of the two groups after the treatment had no significant difference(P>0.05).Electrocardiogram(ECG)and heart function examination had no abnormal performance. Serum NT-proBNP and h-FABP had significant positive correlation(r=0.629,P<0.01),and the correlation was good. Conclusion:Combined detection levels of serum NT-proBNP and h-FABP can early diagnose damage of myocardial cells and heart function in burn patients and can also be used to observe the clinical curative effects.%目的：通过观察烧伤患者早期血清心型脂肪酸结合蛋白（h-FABP）和N末端B型钠尿肽原（NT-proBNP）水平变化，探讨其对早期合并心肌细胞及心功能损害的临床监测价值。方法：选取本院49例合并心肌细胞损害患者（损害组）和50例健康对照组作为研究对象。血清h-FABP检测采用双抗体夹心酶联免疫（ELISA）一步法，血清NT-proBNP检测采用电化学发光免疫分析（ECLIA）法，观察患者治疗前后血清NT-proBNP和h-FABP的水平变化及两者间的相关性分析。结果：烧伤患者治疗前血清h-FABP阳性率（80.3%）明显高于NT-proBNP （50.8%）（P<0.01）。损害组患者治疗前血清NT-proBNP和h-FABP水平均明显高于对照组（P<0.01），治疗后水平明显下降（P<0.01），与对照组比较差异无统计学意义（P>0.05），心电图（ECG）及心功能检测也无异常表现。血清NT-proBNP与h-FABP呈显著正相关（r=0.629，P<0.01），相关性良好。结论：联合检测血清NT-proBNP和h-FABP水平，可早期诊断烧伤患者合并心肌细胞及心功能损害，也可用于临床疗效的观察。