BNP及Copeptin水平与冠状动脉病变程度的相关性研究

摘要

目的：研究脑钠肽（BNP）及和肽素（Copeptin）水平与冠状动脉病变程度的相关性。方法：对本院收治的248例冠心病患者（分为AMI组、SAP组、UAP组）及100例非冠心病患者（对照组）进行BNP及Copeptin水平测定，并评估冠状动脉病变的程度，对各组结果进行比较分析。结果：AMI组、UAP组、SAP组的BNP、Copeptin水平及Gensini积分均显著高于对照组（P<0.05），且AMI组、UAP组、SAP组之间比较差异也具有统计学意义（P<0.05）；左主干病变者的BNP及Copeptin水平显著高于其他病变支数者（P<0.05），而3支病变者显著高于1支与2支病变者（P<0.05），1支病变者与2支病变者差异则无统计学意义（P>0.05）。结论：BNP及和肽素Copeptin水平与冠状动脉病变的程度及病变支数呈正相关，同时也能反映出心肌受损的程度。%Objective:To explore the clinical significance of detection of brain natriuretic peptide(BNP)and copeptin level in patients with coronary heart disease.Method:248 patients with coronary heart disease(group AMI,group SAP,and group UAP)and 100 non-coronary heart disease patients(control group)received detection of BNP and copeptin level,the extent of coronary artery disease were evaluated,the results were compared and analyzed.Result:BNP level,copeptin level and gensini score in group AMI,group SAP,and group UAP were higher than that in control group significantly(P<0.05),comparison of BNP level,copeptin level and gensini score in group AMI,group SAP,and group UAP also showed statistically significant(P<0.05)). BNP and copeptin level in patients with left main coronary artery lesions were higher than other patients(P<0.05), level in patients with three lesions were higher than one and two lesions(P<0.05),patients with one and two lesions showed no significant(P<0.05). Conclusion:Level of BNP and copeptin is positively correlated with number of diseased lesions,and reflects the degree of myocardial damage to some extent.