2型糖尿病患者糖化血红蛋白与C反应蛋白的相关性及其对血管内皮功能的影响

摘要

糖尿病是严重危害人类健康的疾病，其致残、致死的主要原因是血管并发症。糖尿病患者体内同时存在高血糖和炎症性病变，高血糖是糖尿病血管并发症的主要致病因素，而炎性反应是糖尿病及其血管并发症的发病机制之一。糖化血红蛋白（GHb）反映平均血糖水平的高低，C反应蛋白（CRP）与炎症相关，故糖化血红蛋白与C反应蛋白的水平均与糖尿病及其血管内皮细胞功能密切相关。如果在明白了这两者的特性的基础上探究其在2型糖尿病发生血管并发症的过程中所起的作用，再有针对性地阻断某一关键步骤，那么相信在2型糖尿病的治疗及其血管并发症的预防方面都会有很大突破。而糖化血红蛋白与C反应蛋白之间本身也存在着一定的相关性，了解了两者之间的关系，就能更有利于预防、诊治2型糖尿病及其血管并发症。%Diabetes mellitus is a disease which is harm to human’s health seriously,diabetic vascular complications are the leading cause of disability and death. Diabete patients exist hyperglycemia and inflammatory lesions simultaneously in body,hyperglycemia is the main pathogenic factor of diabetic vascular complications,inflammatory reaction is one of the mechanisms on diabetes mellitus and diabetic vascular complications. GHb (Glycosylated hemoglobin)reflects the average blood glucose level,CRP(C-reactive protein)is related to inflammation.Therefore, GHb and CRP are closely related to diabetes mellitus and endothelial function.If we understand both the two characteristics and their functions in the process of type 2 diabetic vascular complications,targeted blocking the key steps,there will be a great progress in the treatment of type 2 diabetes mellitus and in the prevention of vascular complications.There is a correlation between GHb and CRP,understanding the relationship between them,it can be more conducive to prevention, diagnosis and treatment of type 2 diabetes and its vascular complications.