蛋白质芯片技术的临床应用新进展

摘要

近年来，生物芯片技术日趋成熟，这其中，蛋白质芯片技术以其自动化、微型化、高灵敏度、高通量、高特异性等优点，被广泛地应用于蛋白质组学的研究中，并发挥着越来越大的作用。同时，由于此技术能快速、准确地找到细胞与组织在不同环境与状态下蛋白质表达的差异，因此在肿瘤、传染性疾病以及自身免疫性疾病的早期诊断中具有巨大的应用潜能。本文对蛋白质芯片技术的原理、分类与其在临床中的最新应用进展作一总结。%In recent years,biochip technology becomes more mature.Among these,the protein chip technology is playing an increasingly important role in proteomics research for its advantages of automation,miniaturization,high sensitivity, high-throughput and high specificity.Meanwhile,because this technology can quickly and accurately find the difference of protein expression of cells and tissues in different environments and state,it has enormous application potentiality in the early diagnosis of cancer,infectious diseases and autoimmune diseases.This paper makes a summary on the principle and classification of protein chip technology and the progress in its latest clinical application.