过敏状态对儿童哮喘细胞因子反应的影响

摘要

Objective:To study the correlation of cytokines and allergy in children with asthma.Method:80 children with asthma treated from December 2013 to November 2014 in our hospital were selected and divided into allergic group(41 cases) and non-allergic group(39 cases) according to the confirmation of allergy.Meanwhile, there were 40 healthy controls. The level of IL-5, IFN-γand IL-4 of each group was compared.Result:The level of IL-4,IL-5 and IFN in children with asthma were significantly higher than those of control group(P<0.05).The level of IFN-γand IL-5 of allergic group were significantly higher than those of control group(P<0.05),and the level of IL-4 was not significantly different.The level of IFN-γand IL-5 of allergic group was significantly higher than those of non-allergic group(P<0.05),and the level of IL-4 was not significantly different.Conclusion:The allergy has a greater influence on the level of IL-5 and IFN-γfor children with asthma and the state of the children’s illness.%目的：探析哮喘患儿细胞因子水平与过敏状态的相关性研究。方法：入选本院2013年12月-2014年11月小儿哮喘患者80例，根据患儿是否为过敏体质分为过敏组41例、非过敏组39例，同期入选体检健康者40例为对照组，检测比较各组的IL-5、IFN-γ、IL-4水平。结果：小儿哮喘患者的血清IL-4、IL-5、IFN水平显著高于对照组，差异有统计学意义（P<0.05）；过敏组血清IFN-γ、IL-5水平显著高于对照组，差异有统计学意义（P<0.05），而IL-4水平与对照组比较差异无统计学意义；过敏组血清IFN-γ、IL-5水平显著高于非过敏组，差异有统计学意义（P<0.05），而IL-4水平与非过敏组比较差异无统计学意义。结论：过敏状态对哮喘患儿血清IL-5、IFN-γ水平影响较大，可影响患儿病情的严重程度。