皮损内注射治疗瘢痕疙瘩规律停药的临床研究

摘要

Objective:To research the effect of regular withdrawal of Compound Betamethasone in treating keloid by intralesional injection.Method:A total of 156 patients with keloid in our hospital from January 2007 to December 2014 were selected and randomly divided into two groups.There were 81 cases in the experimental group(group A) and 75 cases in the control group(group B).Compound Betamethasone was injected into the keloid lesions of the patients in group A and the drug concentration was gradually decreased in the treatment,while the drug was withdrawn routinely in group B.The therapeutic effect and recurrence rate were compared between the two groups.Result:One month and six months after the treatment,the effect of the two groups had no statistical difference(P>0.01).The recurrence rate of group A was lower than that of group B,the difference was statistically significant(P<0.01).Conclusion:Regular withdrawal of Compound Betamethasone can reduce the recurrence rate in the treatment of keloid.%目的：探讨皮损内注射得宝松规律性停药对治疗瘢痕疙瘩临床效果的影响。方法：选择2007年1月-2014年12月期间到本院就诊的符合瘢痕疙瘩诊断的患者156例，采用随机数字表法将其分成A、B两组，A组为试验组共81例，B组为对照组共75例。A组在瘢痕疙瘩皮损内注射，采取逐渐减少浓度的方法规律停药；B组采用常规疗程停药方法。观察6个月，评估两组患者治疗效果及复发情况。结果：两组在治疗后1个月与治疗后6个月效果差异均无统计学意义（P>O.01）；治疗组复发率低于对照组，两组比较差异有统计学意义（P