巴比妥昏迷疗法在重型颅脑创伤中的临床疗效及预后研究分析

摘要

Objective:To summarize the barbiturate coma therapy in clinical curative effect and prognosis of severe head trauma. Method:82 patients of severe craniocerebral trauma were selected in our hospital from February 2013 to August 2014 during the period of accepted the diagnosis and treatment,and randomly divided into two groups, 41 cases in each group.The control group were underwent routine therapy,while the experimental group was treated barbiturate coma therapy,at the same time,two groups’ treatment and prognosis were contrasted and analyzed. Result:Two groups 24 hours and 48 hours after treatment gived the real-time monitoring,the test results showed that the two groups in the cavity of cerebrospinal fluid pressure and cerebral blood flow and other clinical indicators were dropped. Compared with control group,the experimental group patients clinical index fell more,the difference was statistically significant(P<0.05).Conclusion:The clinical barbiturate coma therapy on the clinical curative effect and prognosis of severe head trauma effect is significant,in addition to being able to control the cerebrospinal fluid pressure in patients with cranial cavity,maximize the cerebral perfusion,at the same time also can improve the patients’ symptoms of cerebral ischemia or hypoxia,plays a comprehensive protection for the brain,thus it has the high feasibility and is worth promoting.%目的：总结巴比妥昏迷疗法在重型颅脑创伤中的临床疗效及预后情况。方法：本次研究资料选自2013年2月-2014年8月期间在本院接受诊治的82例重型颅脑创伤患者，将其随机分为两组，每组各41例患者。对照组接受常规治疗，而试验组则接受巴比妥昏迷疗法，对比及分析两组患者的治疗情况以及预后情况。结果：两组患者治疗24、48 h后给予进行实时监测，其检测结果表明两组患者在颅腔内脑脊液的压力、脑血流量等临床指标方面均有所下降，且与对照组患者比较，试验组患者临床指标下降幅度更大，比较差异有统计学意义（P<0.05）。结论：临床上巴比妥昏迷疗法在重型颅脑创伤中的临床疗效及预后效果较为显著，除了能够控制患者颅腔内脑脊液的压力、最大限度提升其脑灌注之外，还能够改善患者脑缺血或者脑缺氧症状，对于脑组织起着全方位保护作用，因此具有较高可行性，建议推广。