舒芬太尼复合咪唑安定辅助椎管内麻醉临床效果研究

摘要

Objective: To investigate the effect of sufentanil midazolam intraspinal anesthesia clinical effect and application value.Method: In our hospital 90 elective abdominal operation patients with intraspinal anesthesia, were randomly divided into two groups, 45 cases in each group, Ⅰ group sufentanil combined with midazolam, Ⅱ group and fentanyl combined with midazolam, analyze clinical effect of the two groups.Result: After induction of anesthesia, operation began, at the end of Ⅰ group patients with systolic blood pressure, diastolic blood pressure were significantly lower than that of the Ⅱ group, the difference was statistically significant (P<0.05). Analgesic and sedative effect of the Ⅰ group than that of the Ⅱ group, the Ⅱ group to maintain the dosage was small, the onset time of the Ⅰ group than in the Ⅱ group quickly, adverse reaction and inhibition of respiratory complications were less than the Ⅱ group, in the wash and exploration on the abdominal cavity, Ⅰ group had the body movement, and cardiovascular fluctuations than the Ⅱ group was significantly.Conclusion: As adjuvant of spinal anesthesia, the composite sufentanil midazolam sedation and anterograde amnesia effect is good, fast, safe and adverse reaction rate.%目的：探讨舒芬太尼复合咪唑安定辅助椎管内麻醉的临床效果和应用价值。方法：选择90例择期开腹手术的患者行椎管内麻醉，随机数字表法分两组，每组45例，Ⅰ组为舒芬太尼联合咪唑安定，Ⅱ组为芬太尼联合咪唑安定，比较临床效果。结果：在麻醉诱导后、手术开始、结束时Ⅰ组患者的收缩压、舒张压均明显低于Ⅱ组，比较差异有统计学意义（P<0.05）；Ⅰ组对心率与用药前相比的影响比Ⅱ组大，腹腔进行冲洗和探查时，Ⅰ组有体动反应的出现，且心血管波动幅度不如Ⅱ组明显。SpO2Ⅰ组的相关参数略高于Ⅱ组，且诱导中出现SpO2<93%的患者例数Ⅱ组多于Ⅰ组。结论：作为椎管内麻醉的辅助用药，舒芬太尼复合咪唑安定镇静镇痛和顺行性遗忘作用效果好，起效快，安全且不良反应发生率小。