骨折后脑梗死与未合并骨折脑梗死患者血清C-反应蛋白、纤维蛋白原水平比较

摘要

Objective:To compare the level of C-reactive protein and Fibrinogen in the cerebral infarction patients with bone fracture and cerebral infarction patients without bone fracture.Method:The patients in advanced neurology and orthopedic department were selected, including the old bone fracture patients developed cerebral infarction patients,and divided into patients with bone fracture group and patients without bone fracture group,70 cases in each group.The second day after admission the blood was collected, the level of C-reactive protein and Fibrinogen were measured,then statistic analysis of them was used.Result:The level of C-reactive protein and Fibrinogen in patients with bone fracture were higher than patients without bone fracture,they were significiant correlation with cerebral infarction volume,in the same cerebral infarction volume,the level of C-reactive protein and Fibrinogen in patients with bone fracture were higher than patients without bone fracture.Level of CRP and FIB had positively correlated with nerve function damage degree(light,medium,heavy),and the same nerve function damage degree of combined fracture significantly higher than the unincorporated fracture group,the two groups were compared, the difference was statistically significant(P<0.05).So,higher level of C-reactive protein and Fibrinogen in the old patients after bone fracture were danger factors, they could lead to cerebral infarction.Conclusion:C-reactive protein and Fibrinogen were involved in the pathologic process of cerebral infarction,level of C-reactive protein and Fibrinogen may be helpful as objective guides to judging the size of infarction area, nerve function damage degree and prognosis.At the same time, orthopedic surgeon can measure them to prevent the happen of cerebral infarction.%目的：动态比较骨折后脑梗死与未合并骨折脑梗死患者血液C-反应蛋白、纤维蛋白原水平。方法：选择入神经内科及骨科住院的脑梗死患者，包括老年骨折后急性脑梗死患者，分为合并骨折组与未合并骨折组，入院后第2天采集血液，化验C-反应蛋白、纤维蛋白原，对两组上述指标进行统计学分析。结果：合并骨折组C-反应蛋白、纤维蛋白原含量均明显高于未合并骨折组；CRP、FIB水平与脑梗死体积大小呈正相关，并且相同体积合并骨折组明显高于未合并骨折组；CRP、FIB水平与神经功能受损程度（轻型、中型、重型）呈正相关，并且相同神经功能受损程度合并骨折组明显高于未合并骨折组，两组比较均差异具有统计学意义（P<0.05）。从而得出骨折后上述两项指标升高，是老年骨折患者患急性脑梗死的危险因素。结论：CRP、FIB参与脑梗塞的病理过程，检测CRP、FIB可评估脑梗死体积、神经受损程度及预后，同时骨科医生可通过检测两者，预防骨折后脑梗死的发生。