胸腔积液腺苷脱氨酶检测联合酶联免疫斑点实验在结核性胸膜炎诊断中的价值

摘要

目的：研究胸腔积液腺苷脱氨酶（ADA）检测联合酶联免疫斑点实验（T-SPOT）在结核性胸膜炎诊断中的价值。方法：选取112例结核性胸膜炎患者作为观察组，42例非结核引起的渗出性胸腔积液患者为对照组，两组患者均进行胸腔积液ADA检测及T-SPOT实验。结果：两组患者胸腔积液检测结果，ADA敏感性87.50％，特异性88.09%；T-SPOT敏感性为89.28%，特异性为92.85%。两种方法联合检出阳性率为95.54%，与T-SPOT.TB（89.28%）及胸腔积液ADA（87.50%）阳性率比较差异有统计学意义（P<0.05）。结论：两种方法联合检测可提高结核性胸膜炎诊断率，对结核性胸膜炎诊断提供很好的依据，是结核性胸膜炎较好的实验室诊断手段，具有较高的应用价值和广阔的应用前景。%Objective:To study the value of adenosine deaminase from pleural effusions and T-SPOT in diagnosis of tuberculous pleurisy.Method:Selected 112 cases of tuberculous patients as the observation group,42 cases of patiens with non-tuberculous exudative pleural effusion to the control group,two groups of patients were detected both ADA and T-Spot.Result:Two groups of patients with Pleural effusion test results,the sensitivity of ADA and T-Spot were 87.50% and 89.28%,respectively.The specificity of ADA and T-Spot were 88.09% and 92.85%.Combination of two methods of detection positive rate was 95.54%.Two detection methods there was statistically different(P<0.05). Conclusion:Combination of two methods can improve the positive rate,the diagnosis of tuberculous pleurisy provide a good basis,a better laboratory diagnostic tool,has a high value and broad application prospects.