窄谱中波紫外线对慢性荨麻疹患者血清组胺与白三烯的意义

摘要

Objective: To discusses narrow spectrum uvb rays in serum in patients with chronic urticaria of histamine and leukotriene meaning.Method: 40 chronic urticaria patients, were randomly involved into two groups, and were treated by Fexofenadine Hydrochloride Tablets (60 mg, bid) accompanying with NB-UVB (biw) in the trial group, and Fexofenadine Hydrochloride Tablets (60 mg, bid) alone in the control group respectively. Therapeutic courses in both groups were 2 months. Concentration of serum histamine and leukotriene was detected before and after treatments, and (USA) score and dermatological life quality index (DLQI) was used to evaluate the patients’improvements.Result: (1) There was no statistical significance in the study group and the control group before treatment, but after 1 month and 2 months of treatment, there was statistically different (P<0.05). (2) The comparison of serum histamine level before and after treatment of the two groups, the difference was statistically significant (P<0.05), but no significant difference between the two groups after treatment. Comparison of serum leukotriene B4 level before and after treatment in the two groups, the difference was statistically significant (P<0.05), but no statistically significant difference after treatment.Conclusion: Combination therapy of Fexofenadine Hydrochloride Tablets and NB-UVB is beneficial for chronic urticaria, with a significantly higher improvement effect than each single therapy.%目的：探讨窄谱中波紫外线对慢性荨麻疹患者血清组胺与白三烯的意义。方法：将40例慢性荨麻疹患者随机数字表法分为治疗组与对照组，治疗组口服盐酸非索非那定片60 mg，bid，连续2个月，同时辅以NB-UVB治疗2次/周，连续2个月；对照组口服盐酸非索非那定片60 mg，bid，连续2个月。检测血清组胺与白三烯治疗前后的浓度变化情况，监测荨麻疹疾病活动程度（即USA评分）以及皮肤病生活质量指数（即DLQI）。结果：（1）对照组和研究组治疗前USA评分及DLQI评分比较差异无统计学意义，治疗后1个月和2个月USA评分及DLQI评分比较，差异均有统计学意义（P<0.05）。（2）两组治疗前后血清组胺水平比较，差异均有统计学意义（P<0.05），但治疗后比较差异无统计学意义。两组治疗前后血清白三烯B4水平比较，差异均有统计学意义（P<0.05），但治疗后比较差异无统计学意义。结论：NB-UVB联合抗组胺药物可有效改善慢性荨麻疹患者的生活质量，提高疗效。