多囊卵巢综合征行体外受精-胚胎移植助孕结局分析

摘要

目的：探讨多囊卵巢综合征（PCOS）伴不孕患者采用体外受精-胚胎移植（IVF-ET）助孕治疗的疗效及特点。方法：回顾分析2013年52周期PCOS不孕因素IVF-ET病历资料作为A组，同期102周期输卵管因素IVF-ET病例作对照作为B组。结果：PCOS组与输卵管因素组比较分析：患者年龄、不孕年限、BMI、Gn天数、获卵数、可移植胚胎数、OHSS风险取消移植率比较，差异有统计学意义（P<0.05）。PCOS组患者较输卵管因素组更年轻，不孕时间短、体重指数高，Gn时间长，获卵数多，相应可移植胚胎多，OHSS风险明显升高。而两组Gn用量、内膜厚度、2PN受精率、卵裂率、优胚率及临床妊娠率等差异均无统计学意义（P>0.05）。结论：PCOS伴不孕患者采用IVF-ET助孕可获得与输卵管因素IVF-ET助孕相似的疗效，但要注意OHSS的风险预防。%Objective:To evaluate the polycystic ovary syndrome (PCOS) with infertility were treated by in vitro fertilization-embryo transfer (IVF-ET) curative effect and characteristics of assisted reproduction treatment. Method: 52 cycles PCOS infertility factor in IVF-ET medical records in 2013 year were analysed retrospectively as group A, and 102 cycles tubal factor IVF-ET cases in the same period as controls of group B.Result:Compared PCOS group and tubal factor group analysis: age, infertility time, BMI, the number of eggs, portable designed the Gn days, embryo number and risk of OHSS cancel graft rate comparison, the difference was statistically significant(P<0.05). PCOS patients compared with tubal factor group more young, shorter infertility time, higher body mass index (BMI),longer Gn time,more egg number, more corresponding portable embryos and OHSS risk increased significantly. But two groups of designed the Gn dosage, endometrium thickness, 2 PN fertilization rate, cleavage rate, good embryo rate and the clinical pregnancy rate were no statistically significant difference.Conclusion:PCOS patients of infertility with the IVF-ET assist reproduction can be obtained IVF-ET assist similar curative effect with the tubal factor, but should pay attention to prevent the risk of OHSS.