早期检测糖尿病肾病患者血清胱抑素C的意义

摘要

Objective:To explore the significance of early detection of serum cystatin in clinical diagnosis on patients with diabetic nephropathy.Method:A total of 128 cases of diabetes in our hospital from February 2012to June 2015 were selected as the research objects,of which 64 patients with simple type 2 diabetes were set as group A,64 patients with early diabetic nephropathy were set as group B,64 cases of healthy controls during the same period were chosen as the control group,Cys-C,serum creatinine(Scr) and urea nitrogen(BUN) levels of the three groups were detected respectively.Result:The levels of serum Cys-C,Scr and BUN in both of group A and group B were higher than which of the control group,the serum Cys-C in group B was significantly higher than group A,the differences were statistically significant(P<0.05).However,serum Scr and BUN levels between the group A and B had no statistical significance(P>0.05).In group B,patients with Cys-C positive detection were 37 cases(57.81%),which was significantly higher than 21.88%(14/64)of the Scr detection and 18.75%(12/64) of the BUN detection,the differences were statistically significant(P<0.05).Cys-C level was positively correlation with levels of Scr and BUN in group B,the differences were statistically significant (r=0.791,0.702, P<0.05).Conclusion:Early detection of serum Cys-C can be beneficial to the clinical diagnosis of early diabetic nephropathy,it has an important clinical value.%目的：探讨早期检测糖尿病肾病患者血清胱抑素C（Cys-C）在临床诊断中的意义。方法：选取本院2012年2月-2015年6月收治的128例糖尿病患者为研究对象，其中单纯性2型糖尿病患者64例，设为甲组；早期糖尿病肾病患者64例，设为乙组；同时选取同期健康体检者64例为对照组，分别检测三组受试者的血清Cys-C、肌酐（Scr）及尿素氮（BUN）水平。结果：甲、乙两组血清Cys-C、Scr及BUN水平均明显高于对照组，乙组血清Cys-C水平明显高于甲组，比较差异均有统计学意义（P<0.05）；而甲、乙两组间血清Scr及BUN水平比较，差异均无统计学意义（P>0.05）。乙组中，Cys-C阳性检出者为37例，占57.81%，明显高于Scr的21.88%（14/64）和BUN的18.75%（12/64），比较差异均有统计学意义（P<0.05）；乙组患者Cys-C水平与血清Scr、BUN均呈正相关性（r=0.791、0.702， P<0.05）。结论：早期检测血清Cys-C可有利于临床诊断早期糖尿病肾病，具有重要的临床价值。