非淋菌性阴道炎与胎膜早破早产的关系及对围生儿的影响

摘要

Objective:To explore the relationship between the non-gonococcus vaginitis pathogen UU、CT、BV infection in pregnant women and preterm premature rupture of membranes(PPROM),further to analyze the impact of the infection on perinatal infants.Method:260 pregnant women with PPROM in our hospital from January 2013 to March 2015 were selected as the observation group,260 healthy pregnant women at the same period were selected as the control group.The samples of vagina and cervix secretions of the pregnant women were obtained for the detection of CT、UU and BV,the chorionic amniotic membrane of every pregnant women should be checked.The condition of the perinatal infants was observed and the results were analyzed.Result:The detection rate of CT,UU and compound infection in the observation group were significantly higher than those in the control group,the differences were statistically significant(P<0.01).The difference in the detection rate of BV infection between the two groups was not statistically significant(P>0.05).The incidence rate of chorioamnionitis in the observation group was significantly higher than that in the control group,the difference was statistically significant (P<0.01).The incidence rates of low birth weight,neonatal pneumonia and neonatal ophthalmia in the single infection group and the coinfection group were all higher than those in the negative infection group,the differences were statistically significant(P<0.01).Conclusion:The causes of PPROM are related to non-gonococcus vaginitis closely.The prevalence rate of the perinatal infants whose mothers were with non-gonococcus vaginitis increased. The screening for non-gonococcus vaginitis before and during pregnancy shall be strengthened and the etiological treatment shall be given to the pregnant women in order to reduce the occurrence of PPROM and reduce the morbidity of perinatal infants.%目的：探讨非淋菌阴道炎致病菌支原体（UU）、衣原体（CT）、细菌（BV）导致的感染与孕妇胎膜早破早产的关系，并进一步分析其对围生儿的影响。方法：选择本院2013年1月-2015年3月胎膜早破早产的孕妇260作为观察组，并以同期住院健康孕妇260例为对照组，对孕妇阴道及宫颈分泌物行CT、UU、BV检测，并行绒毛膜羊膜检查，同时观察围生儿情况，对结果进行分析。结果：观察组UU、CT及复合感染检出率均明显高于对照组，比较差异均有统计学意义（P<0.01）；两组BV感染检出率比较，差异无统计学意义（P>0.05）；观察组绒毛膜羊膜炎发生率高于对照组，比较差异有统计学意义（P<0.01）；单一感染组及复合感染组围生儿低体重、新生儿肺炎及新生儿结膜炎的发生率均明显高于阴性感染组，比较差异均有统计学意义（P<0.01）。结论：胎膜早破早产与非淋菌性阴道炎关系密切，且围生儿发病率增高，孕前及孕期应加强对非淋菌阴道炎的筛查，尽早行对因治疗，以降低胎膜早破早产的发生，并降低围生儿发病率。