不同剂量阿托伐他汀在脑梗死患者治疗中的应用探讨

摘要

目的探讨不同剂量阿托伐他汀在治疗脑梗死患者中临床疗效。方法随机选取我院近年来收治的120例脑梗死患者,随机分为A、B、C三组,每组40例,A组：采取常规治疗。 B、C组：在A组治疗的基础上,分别服用阿托伐他汀10mg/d、20mg/d治疗。2w后观察每组血脂、血清hs-CRP及神经功能的改善程度。结果治疗后,B、C组在改善血脂水平及血清hs-CRP方面均显著优于A组,且C组效果更好；C组的NIHSS评分也显著低于B组,差异具有统计学意义(<0.05)。结论阿托伐他汀在治疗急性脑梗时,具有较好的临床疗效,且20mg治疗效果更佳。%Objective To investigate the effects of dif erent doses of atorvastatin in the treatment of cerebral infarction in patients with clinical ef icacy. Methods In our hospital in recent years treated 120 cases with cerebral infarction were randomly divided into A, B, C3 group, 40 cases in each group, group A: take the conventional treatment. B, C group: A group based on the treatment of atorvastatin, respectively 10mg / d, 20mg / d treatment. Degree of improvement were observed after 2 weeks of blood lipid, serum hs-CRP and neural function. Results After the treatment, B, C group in improvement of blood lipid level and serum hs-CRP were significantly better than those in A group, and C group was best; group C NIHSS score was significantly lower than that of B group (P<0.05). Conclusion Atorvastatin in the treatment of acute cerebral infarction, the clinical ef icacy is good, and bet er therapeutic ef ect of 20mg.