目的探讨呼出一氧化氮（FeNO）在儿童哮喘诊治中的意义。方法选取哮喘儿童72例，分为FeNO组GINA组。比较两组患儿病情严重程度评分（ASS）、抗生素使用率及诊疗花费。结果 FeNO组在6个月(G2)、1年后(G3)FeNO值分别为29±12ppb、16±7ppb，较治疗前(G1)FeNO值明显下降；在研究初始两组ASS、抗生素使用率（%）和诊疗花费/月无明显差别（跃0.05），FeNO组ASS在6个月(G2)、1年后(G3)分别为0.52±0.46、0.65±0.49，较GINA组明显下降(约0.01)；抗生素使用率（%）和诊疗花费/月在6个月(G2)、1年后(G3)均较GINA组明显下降（约0.01）。结论动态监测哮喘儿童的FENO值，可预测哮喘儿童发作风险，判断患儿哮喘发作与感染的关系，减少哮喘儿童抗生素的使用率，降低诊治哮喘的费用。%Objective To investigate the value of fraction of exhaled nitric oxide in the diagnosis and treatment of childhood asthma. Methods 72 children with asthma were were divided into FeNO group and GINA group. Compare two groups of children with the Asthma Severity score (ASS), the antibiotic usage rate and the charge for diagnosis and treatment. Results The mean FeNO were 29±12ppb、16±7ppb at 6 months and 1 year after, distinctly decreased compared with the mean FeNO group at the start study ( 约0.05 ). It did not show any significant dif ierence between the two groups at the start of the study in ASS , the antibiotic usage rate and the charge for diagnosis and treatment( 跃0.05). ASS mean values significantly decrease in the FeNO group at G2 (0.52±0.46) and G3 (0.65±0.49) compared with the GINA group. Both the antibiotic usage rate and the charge for diagnosis and treatment were in the FeNO group at G2 and G3 ignificantly decrease in the FeNO group compared with the GINA group ( 约0.01). Conclusion Continuous monitoring of FeNO can predict the risk of asthma at ack in children, judge the relationship between the asthma attack in children and infection. and reduce the antibiotic usage rate and the charge for diagnosis and treatment.
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