2013年克拉玛依市手足口病实验室检测病原学分析

摘要

目的了解2013年克拉玛依市手足口病流行期间患病儿童的病原类型和流行状况。方法采集患者粪便提取病毒核酸，采用real-time PCR方法进行肠道通用病毒、EV71和CA16检测。结果研究对象中，男女比例2.69：1，年龄1~22岁，其中2~3岁年龄段占47.4%。肠道病毒阳性率89.8%，EV71、CA16、非EV71非CA16的其他肠道病毒分别占肠道病毒67.9%、18.9%和13.2%。结论2013年克拉玛依市手足口病发病人群多在7岁以下，2~3岁儿童为病毒主要感染目标。男性发病人数多于女性，各病原阳性率在不同性别中无统计学差异。 EV71是克拉玛依市2013年手足口病优势病原体。%Objective To study the etiology of hand-foot-and-mouth disease among sick children in Karamay in 2013. Methods Stool specimens were col ected and then detected by real-time PCR for various enterovirus,EV71 and CA16.Results Male/female ratio was 2.69:1 among objects, the youngest was one-year-old, the oldest was 22 years old,47.4% of patients were 2 or 3 years old, the positive rate of enterovirus was 89.8%,the rate of EV 71,CA16 and non-EV71/CA16 was 67.9%,18.9% and 13.2%. Conclusion The majority of patients were under 7 years old, the children during 2~3 years old were the main infective targets.More men than women were infected but there was no statistical differenceof positive rate of pathogeny in the sex. The main causative agent of hand-foot-and-mouth disease was EV71 in Kamaray in 2013.