Polypharmacy is an increasing concern in the management of inflammatory bowel disease.This review describes drug interactions in the combination therapy of inflammatory bowel disease,including aminosalicylate ,corticosteroid,azathioprine,methotrexate,cyclosporine,thalidomide,cyclophosphamide and antibiotics,TNF inhibitor.%氨基水杨酸制剂、肾上腺糖皮质激素、硫唑嘌呤、甲氨蝶呤、环孢素、沙利度胺、环磷酰胺、抗肿瘤坏死因子α单克隆抗体等药物在炎症性肠病(Inflammatory bowel dis-ease,IBD)治疗应用较广。目前多种药物联合应用在 IBD 治疗中越来越常见,药物之间的相互作用也日益受到医学界的重视。现介绍 IBD 治疗中常见的药物联用对彼此血药浓度、毒副作用、治疗效果等的影响。
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