为增强磁流体在肿瘤治疗中的靶向性,本研究在制备磁流体过程中加入Cu2＋,利用超声乳化法制备纳米CuxFe1-xO.Fe2O3颗粒,采用壳聚糖作为表面活性剂制备出分散均匀、稳定性好的水基磁流体,研究了不同的Cu2＋加入量和不同的壳聚糖用量对磁流体磁性能的影响.结果表明：壳聚糖成功包覆于磁性CuxFe1-xO.Fe2 O3颗粒的表面;不同Cu2＋加入量制得的粉末同属立方晶系;当实验原理方程式中的x=0.1、壳聚糖溶液用量为20 mL（每50 mL质量分数为1%的CuxFe1-xO.Fe2 O3溶液）时进行表面改性制得的纳米磁流体具有较高的比饱和磁化强度及稳定性,静置30 d后,无明显沉降及分层现象,其比饱和磁化强度为56.43 A.m2.kg-1.%In order to increase the magnetic fluid in target-based in cancer treatment,the Cu2＋ was studied in the preparation procedure.Nano-CuxFe1-xO·Fe2O3 magnetic particles were prepared by means of ultrasonic emulsion method,and then dispersed into water with chitosan as surfactants to make CuxFe1-xO·Fe2O3 magnetic fluid.The influence of Cu2＋ addition and chitosan on the magnetic properties was studied.The results show that the surface of CuxFe1-xO·Fe2O3 nanoparticle is wrapped with chitosan.The CuxFe1-xO·Fe2O3 nanoparticles with different of the Cu2＋ addition are cubic system.It is conducive to obtain the CuxFe1-xO·Fe2O3 magnetic fluid with a high saturation magnetization and stability when the condition for x=0.1 and chitosan solution dosage is 20 ml（every 50 ml of the CuxFe1-xO·Fe2O3 solution（1 % by weight））.Rest for 30 days,there is no obvious phenomenon of settled and stratified,and the saturation magnetization is 56.43 A·m2·kg-1.
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