A macro-chain transfer agent(PLA macro-CTA) was synthesized by the ring opening polymerization of lactide(LA) in the presence of stannous octoate as catalyst and 2-(ben-zylsulfanylthiocarbonylsulfanyl) ethanol as initator, then chain extension of PLA via reversible addition-fragmentation chain transfer (RAFT) radical polymerization of N, N-dimethylamino-2-ethyl methacrylate (DMAEMA) resulted in the formation of amphiphilic PLA-b-PD-MAEMA copolymer. The nuclear magnetic resonance spectroscopy(1 HNMR and 13CNMR) , fourier transform infrared spectroscopy(FT-IR) and gel permeation chromatography(GPC) were employed to characterize the structure of the polymers, and performance test was carried out by contact angle meter and thermogravimetric analysis (TGA). The results showed that the copolymer with narrow molecular mass distribution was successfully synthesized. The hy-drophilicity and thermal stability of polylactide were improved due to the influence of PDMAEMA.%以2-苄基三硫代碳酸酯基乙醇为引发剂,在辛酸亚锡催化下引发丙交酯(LA)开环聚合,合成大分子链转移剂PLA macro-CTA,加入第二单体聚甲基丙烯酸N,N-二甲氨基乙酯(DMAEMA),通过可逆—加成—断裂链转移(RAFT)自由基聚合,得到两亲性嵌段共聚物PLA-b-PDMAEMA.采用核磁共振光谱(1HNMR和13 CNMR)、红外光谱(FT-IR)及凝胶色谱(GPC)对合成的共聚物化学结构进行表征,并通过接触角测试和热重分析(TGA)对其进行性能测试.结果表明成功合成了嵌段共聚物且分子量分布指数较窄；引入PDMAEMA链段后聚乳酸的热稳定性和亲水性得到提高.
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