The patients with lumber degenerative spondylolisthesis often have to undergo surgical treatment. Conventional surgical approach is performed by bilateral pedicle screw fixation in lumbar interbody fusion, and this maybe accelerate segment degeneration of adjacent vertebral bodies. The recent studies indicate that unilateral pedicle screw fixation in lumbar interbody fusion can achieve the same effect on stability and interbody fusion by using conventional bilateral pedicle screw fixation in lumbar interbody fusion,.and prevent from segment degeneration of vertebral bodies. But the operation indication must be restrictedly controlled, the operation technique be skilled.%保守失败的腰椎退行性疾病常需要手术治疗,传统的双侧椎弓根螺钉腰椎融合术可能增加邻近节段退变的发生率。近年研究表明,单侧椎弓根螺钉结合椎体间融合术治疗腰椎退行性疾病可获得与传统双侧椎弓根螺钉固定相似的稳定性与融合率,并可预防固定融合节段的邻近节段退变,但应用单侧椎弓根螺钉固定需要严格掌握手术适应证。
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