目的：观察利巴韦林、炎琥宁治疗婴幼儿轮状病毒肠炎的临床疗效。方法：将我院诊疗的婴幼儿轮状病毒肠炎患者236例随机分为利巴韦林组（A组）、炎琥宁组（B 组）、对照组（C 组），再按入院时距发病时间分为病程0-48 h 组，病程＞48 h 组。 C 组仅给予补液、维持水电解质平衡等基础治疗；A 组加用利巴韦林（10-15） mg/（kg·d）静脉滴注，B 组加用炎琥宁（5-8）mg/（kg·d）静脉滴注，比较各组患儿发热持续时间、退热时间、腹泻性状及次数恢复正常时总病程时间。结果：在病程0-48 h 组中，A 组、B 组的退热时间均明显短于 C 组，B 组总病程明显短于C 组，P 均＜0．05；在病程＞48 h 组中，A组、B 组、C 组退热时间均无明显差异，B 组总病程短于A组、C 组。结论：在起病0-48 h 间使用利巴韦林、炎琥宁有助于轮状病毒肠炎患者退热，使用炎琥宁可缩短病程，有助于改善腹泻症状。%To observe the clinical effect of Ribavirin and Yanhuning for patients with infantile rotavirus enteritis. Method: 236 patients with infantile rotavirus enteritis were randomly divided into Ribavirin group (group A)、Yanhuning group(group B)and control group (group C). Among the three groups,there were divided into 0-48 h group and > 48 h group according the onset time to in-hospital. Based on the group C granted rehydration , maintain water and electrolyte balance, group A was given Ribavirin (10-15) mg/ (kg·d), intravenous drip, group B was given Yanhuning (5-8) mg/(kg.d), intravenous drip. The fever duration, fever to normal time, number of traits and diarrhea, the overall course were compared among the three groups. Results: At the 0-48 h groups, antifebrile time in both the group A and group B were significantly shorter than that in the group C , overall duration in group B was significantly shorter than that in the group C, all P<0.05. At the>48 h groups, antifebrile time in the three groups were no significant difference, but overall duration in group B was shorter than that in the other two groups. Conclusion: Using Ribavirin and Yanhuning can help antifebrile for patients with infantile rotavirus enteritis during the onset 0-48 hours , and Yanhuning may short the overall duration and help to improve symptoms of diarrhea for the cases.
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