肥胖人群脂联素、抵抗素和胰岛素抵抗水平的研究

摘要

Objective To investigate the levels of serum adiponectin, resistin and insulin resistance levels of the obese people in Guangzhou area.Methods The body mass index (BM1), waist line, hip circumference, fasting insulin, fasting glucose, blood lipids, adiponectin and resistin levels were determined in 106 obese subjects and 107 healthy controls respectively, and the homeostasis model assessment-insulin resistance index (HOMA-IRI) was calculated.Results There was statistical significance of BMI, body fat percentage (BF), HOMA-IRI, resistin,adiponectin, total cholesterol (TC) and apolipoprotein B (apo B) between the obese subjects and the healthy controls (P ＜0.01, P ＜0.05 ).There was positive correlation between adiponectin and resistin with BMI, BF and HOMA-IRI [adiponectin: coefficient correlation (r) =0.439(P＜0.01), r=0.236(P＜0.01), r=0.398(P＜0.01 );resistin: r = 0.296 ( P ＜ 0.01 ), r = 0.175 ( P ＜ 0.05 ), r = 0.827 ( P ＜ 0.01 )].There was positive correlation between resistin and waist-hip-ratio(WHR) (r = 0.169, P ＜ 0.05 ).Conclusions Adiponectin may predict the BMI and HOMA-IRI,and resistin can predict BMI.The change of adiponectin and resistin levels may lead to obesity and insulin resistance,and adiponectin and resistin have some influence on the occurrence and development of diabetes mellitus.%目的 探讨肥胖患者血清脂联素、抵抗素和胰岛素抵抗水平的变化及意义.方法 分别测定106例肥胖者和107名健康对照者的体重指数(BMI)、腰围、臀围、空腹胰岛素、空腹血糖、血脂、脂联素和抵抗素水平,计算胰岛素抵抗指数(HOMA-IRI). 结果 肥胖者的体重指数(BMI)、体脂分布百分比(BF)、HOMA-IRI、抵抗素、脂联素、总胆固醇(TC)、载脂蛋白B(apo B)与健康对照组比较,差异均有统计学意义(P<0.01、P<0.05).脂联素和抵抗素均与BMI、BF和HOMA-IRI呈正相关([脂联素:相关系数(r)分别为0.439、0.236、0.398,P均<0.01;抵抗素:r分别为0.296(P<0.01)、0.175(P<0.05)、0.827(P<0.01)],抵抗素与腰臀比(WHR)呈正相关(r=0.169,P<0.05).结论 脂联素能较好地预测BMI和HOMA-IRI,抵抗素能较好地预测BMI.脂联素与抵抗素水平的变化可能导致肥胖和胰岛素抵抗,在向糖尿病的发生发展过程中起了一定作用.