脑外科监护病房肺炎克雷伯菌的耐药情况分析

摘要

Objective To analyze the antibiotic resistance and characteristic of Klebsiella pneumoniae isolated from neurosurgical intensive care unit in Huashan Hospital.Methods A total of 233 Klebsiella pneumoniae isolates were collected from neurosurgical intensive care unit.Antibiotic susceptibility of the isolates was determined.Results A total of 77.3%of 233 isolates of Klebsiella pneumoniae were collected from respiratory tract samples.The total resistance rates to antibiotics increased year after year.The resistance rates to piperacillin-tazobactam,cefoperazone-sulbactam, imipenem,meropenem and ertapenem for respiratory tract samples were obviously lower than those for non-respiratory tract samples (P<0.05 ).Conclusions There is a contrast between the antibiotic susceptibility of the respitatory specimens and the non respiratory specimens.The monitoring of nosocomial infection should be strengthened to avoid misusing antibiotics.%目的：了解华山医院脑外科监护病房肺炎克雷伯菌的耐药情况及其特点。方法收集脑外科监护病房送检标本分离出的肺炎克雷伯菌233株进行药物敏感性试验。结果233株肺炎克雷伯菌中77．3％来源于呼吸道标本，总体耐药率逐年提升。呼吸道标本分离出的肺炎克雷伯菌对哌拉西林-他唑巴坦、头孢哌酮-舒巴坦、亚胺培南、美罗培南以及厄他培南耐药率明显低于非呼吸道标本（P＜0．05）。结论呼吸道标本分离出的肺炎克雷伯菌和非呼吸道标本分离出的肺炎克雷伯菌对药物敏感性存在差异，必须继续加强医院感染监控，避免滥用抗菌药物。