血清淀粉样蛋白A与C反应蛋白联合检测在新生儿细菌感染诊断中的应用

摘要

目的：研究血清淀粉样蛋白 A（SAA）和 C 反应蛋白（CRP）以及白细胞总数在新生儿细菌感染诊断中的应用价值。方法分别检测80例细菌感染新生儿及58名体检正常的新生儿（非感染组）SAA、CRP 和白细胞总数并做比较。结果新生儿细菌感染组 SAA 与 CRP 水平分别为（67.3±38.4）、（19.2±11.2）mg/L，明显高于非感染组[（8.7±2.1）、（5.6±2.5）mg/L]（P<0.05）。80例新生儿细菌感染组中有64例（80%）白细胞总数>15.00×109/L，明显高于非感染组[24例（41%）]。结论 SAA 和 CRP 可作为新生儿细菌感染诊断的重要指标，SAA 较 CRP 更为敏感，SAA 与 CRP 的联合检测能够提高新生儿细菌感染的检出率，为疾病的早期诊断和监测提供实验依据。%Objective To study the significance of serum amyloid A(SAA),C-reactive protein(CRP)and white blood cell count determinations for diagnosis of bacterial infection in neonates. Methods SAA,CRP and white blood cell count were determined in 80 neonates with bacterial infection and 58 healthy neonates(non-bacterial infection group),and the results were analyzed. Results The concentrations of SAA and CRP in infection group [(67.3±38.4)and(19.2±11.2) mg/L] were significantly higher than those in non-bacterial infection group [(8.7±2.1)and(5.6±2.5)mg/L](P<0.05). The white blood cell count was >15.00×109/L in 64 neonates of 80 cases of infection group(80%),which was higher than that in non-bacterial infection group [24 cases(41%)]. Conclusions SAA and CRP could be used as important markers for monitoring bacterial infection in neonates,and SAA is more sensitive than CRP. The combined determination of SAA and CRP could improve the determination rate of bacterial infection,which provides an experimental reference for early diagnosis and monitoring of bacterial infection.