目的 探讨网织红细胞(RET)各参数在新生儿溶血病(HDN)治疗中的价值,为临床判断疗效提供参考.方法 对44例HDN患者于入院当天、治疗中、出院当天3个时间点取末梢血,测定网织红细胞计数百分比(RET％)、未成熟网织红细胞百分比(IRF％)、低荧光强度网织红细胞百分比(LFR％)、中荧光强度网织红细胞百分比(MFR％)、高荧光强度网织红细胞百分比(HFR％)共5个指标,以入院当天各指标为基线,分析治疗中、出院当天各参数的变化.结果 随治疗的进行,RET％、IRF％、HFR％、MFR％呈进行性下降,LFR％呈进行性上升.RET％明显降低者占患者总数的84.09％.在明显降低组中,出院时RET％、IRF％、MFR％、HFR％与入院时相比差异有统计学意义(P<0.05),RET％下降与IRF％、HFR％下降呈正相关(r值分别为0.632、0.639,P<0.01).在无明显降低组中,出院时RET％、IRF％、MFR％、HFR％与入院时相比,差异均无统计学意义(P>0.05).结论 RET％可作为监测MDN治疗过程中比较敏感的指标.当RET％下降明显时,提示治疗有效.同时,IRF％、HFR％和LFR％可作为监测HDN治疗的辅助指标.%Objective To investigate the role of reticulocyte(RET) parameters in the treatment of hemolytic disease of newborns(HDN),and to provide a reference for evaluating treatment efficiency.Methods Peripheral blood samples of 44 patients with HDN were collected on the days of admission,treatment and discharging, respectively. All samples were determined for reticulocyte percentage(RET％),immature reticulocyte fraction percentage(IRF％),low fluorescence reticulocyte percentage(LFR％),medium fluorescence reticulocyte percentage(MFR％) and highfluorescence reticulocyte percentage(HFR％). The results on the day of admission were as baselines,and the change trend of the results on the days of treatment and discharging were evaluated. Results The RET％,IRF％,MFR％ and HFR％ decreased,and LFR％ showed an increase with the treatment progressed. RET％ was decreased,which accounted for 84.09％. In decreased group,RET％,IRF％,MFR％ and HFR％ on the day of discharging had statistical significance compared with those on the day of admission(P<0.05). The decrease of RET％ was positively correlated with those of IRF％ and HFR％ in decreased group(r=0.632 and 0.639,P<0.01). There was no statistical significance for RET％,IRF％,MFR％ and HFR％ between the days of admission and discharging(P>0.05).Conclusions RET％ could be used as a sensitive indicator in monitoring the treatment of HDN. The decreasing of RET％ indicates that the treatment is effective. IRF％,HFR％ and LFR％ could be used as auxiliary indicators for monitoring HDN treatment.
展开▼
