某地区5089例中晚期妊娠妇女血清甘胆酸分析

摘要

Objective To investigate distribution characters of serum cholvglycine (CG) levels in women dur-ing middle and late pregnancy in Tongling ,and to provided evidence for the diagnosis and treatment of intrahepatic cholestasis of pregnancy (ICP) .Methods Serum CG level was detected in 5 089 cases of women during middle and late pregnancy from Jan .2010 to Dec .2012 by using radioimmunity assay .Results 72 .10% of all enrolled women were with normal level of serum CG and 7 .35% were with obviously increased level of serum CG .The positive rate of increased CG level in pregnant women at least 35 years old were significantly higher than pregnant women of 20-34 years old (P<0 .05) .Conclusion The monitoring of serum CG level might be with significant value for the diag-nosis and treatment of ICP .Advanced age could be a possible high risk factor for ICP .%目的了解铜陵地区中晚期妊娠妇女血清甘胆酸（CG）浓度的分布，为妊娠肝内胆汁淤积症（ICP）的诊断和治疗提供依据，并分析其与妊娠年龄的关系。方法2010年1月至2012年12月于该院进行检查的妊娠妇女5089例，用放射免疫法测定其血清CG浓度。结果妊娠妇女CG值正常的占72．10％，明显升高的占7．35％；其中高龄（≥35岁）妊娠妇女组CG升高率与适龄（20～34岁）组比较差异有统计学意义（ P＜0．05）。结论血清CG浓度监测对ICP的诊断和治疗具有重要价值，高龄可能是诱发ICP的高危因素之一。