大龄经产妇性激素水平调查及其对再生育的影响

摘要

目的：探讨性激素水平对大龄经产妇再生育的影响。方法回顾性分析2009年4月至2013年4月都江堰市医疗中心就诊的437例35岁以上经产妇的临床资料，按孕育结果分为正常孕育组（118例）和非正常孕育组（319例），所有产妇均测定血清雌二醇（E2）、催乳素（PRL）、黄体生成素（LH）、促卵泡激素（FSH）、孕酮（P）和睾酮（T ）水平，探讨各性激素水平对大龄经产妇再孕再育的影响。结果非正常孕育组妇女血清E2水平明显低于正常孕育组，而PRL、LH、FSH水平明显高于正常孕育组，组间比较差异有统计学意义（P＜0．05）；多因素Logistic回归分析显示，影响大龄经产妇再孕再育的主要因素为E2和FS H。结论大龄经产妇中非正常孕育组血清FS H水平明显升高，E2、FS H水平是影响大龄经产妇不孕不育的主要因素。%Objective To investigate the sex hormone levels of elder multiparous women ,and explore their in‐fluence on re‐pregnancy .Methods A total of 437 elder multiparous women were divided into normal‐pregnancy group and abnormal‐pregnancy group .The serum levels of estradiol(E2) ,prolactin(PRL) ,luteinizing hormone(LH) , follicle‐stimulating hormone(FSH) ,progesterone(P) and testosterone(T ) were detected and analyzed .Results The serum E2 level of abnormal‐pregnancy group was significantly lower than that in normal‐pregnancy group ,while PRL ,LH and FSH levels were significantly higher than those in normal‐pregnancy group (P<0 .05) .The result of multivariate Logistic regression analysis showed that the main factors affecting re‐pregnant of the elder multipara were E2 and FSH .Conclusion The serum FSH level might be increased significantly in elder multiparous women with abnormal‐pregnancy ,and the levels of E2 and FSH could be the main factors affecting infertility in elder women .