目的：探讨 N-末端脑钠肽前体（NT-proBNP）、肌钙蛋白（cTnI2）、肌红蛋白（MYO）、肌酸激酶同工酶MB（CK-MB）水平在慢性心力衰竭（CHF）患者中的意义。方法选择谷城县中医院2009年6月至2012年6月209例 CHF 患者为研究对象。依据美国纽约心脏病协会分级对患者进行心功能分级，并对各级患者的 NT-proB-NP 、cTnI2、MYO 、CK-MB 水平进行检测，并与60例健康体检者进行对比分析。结果 CHF 患者的 NT-proBNP水平明显高于对照组（P＜0．05），且 CHF 各级患者间 NT-proBNP 水平比较，差异有统计学意义（P＜0．05）。各级CHF 患者的 cTnI2、MYO 、CK-MB 水平随着病情的发展逐渐增加，但差异均低于 NT-proBNP 水平（P ＜0．05）。结论通过检查 NT-proBNP 水平的变化可以对 CHF 患者的疾病发展进行预测。%Objective To explore the levels of N-terminal probrain natriuretic peptide (NT-proBNP) ,cardiac troponin I2 (cTnI2) ,myoglobin (MYO) and creatin kinase myocardial type MB (CK-MB) in patients with chronic heart failure (CHF) .Methods A total of 209 patients with CHF from Jun .2009 to Jun .2012 were selected into CHF group ,60 healthy people were selected as control group .Patients were divided into four groups based on the heart function classification assay of American heart association (NYHA ) .The levels of NT-proBNP ,cTnI2 ,MYO and CK-MB were detected and compared in the two groups .Results The level of NT-proBNP in the CHF group was sig-nificant higher than that of the control group(P < 0 .05) .There were significant differences on the level of NT-proB-NP in four heart function classification groups (P< 0 .05) .The levels of cTnI2 ,MYO ,and CK-MB in four heart func-tion classification groups increased as the disease developed ,but the differences were still lower than the level of NT-proBNP .Conclusion The level of NT-proBNP in patients with CHF could predict the progress of this disease .
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