Objective To explore the relationship between the expression of breast cancer susceptibility gene 1 (BRCA-1) and human growth factor receptor 2(HER-2) gene and the breast cancer .Methods Data of 85 patients with mastectomy therapy from January to December in 2013 were studied .BRCA-1 immunohistochemistry method was used to monitoring the hybridization ,HER-2 was detected by fluorescence restoration hybridization .Compared the differences of BRCA-1 and HER-2 gene in different pathological types and whether patients with lymph node me-tastasis or not .Results The positive rate of BRCA-1 in intraductal carcinoma ,infiltrating ductal carcinoma and me-dullary carcinoma of breast were 62 .3% (5/8) ,77 .3% (54/70) ,71 .4% (5/7)respectively ,the differences among the three types were significant(P<0 .05) .The positive rate of BRCA-1 in patients with lymph node metastasis and no lymph node metastasis were 88 .6% (31/35) ,25 .0% (10/40)respectively ,the difference between them was not signif-icant(P<0 .05) .Conclusion BRCA-1 gene ,HER-2 gene has close relationship with the occurrence and development of breast cancer ,which is important for early prevention ,diagnosis ,treatment of breast cancer .%目的：探讨乳腺癌标本中乳腺癌易感基因1（BRCA-1）和原癌基因人类表达生长因子受体2（HER-2）与疾病的相关性。方法选择百色市人民医院2013年1～12月乳腺外科手术切除患者85例，BRCA-1采用免疫组化法检测，HER-2采用荧光复位杂交检测。比较BRCA-1基因和 HER-2在不同病理类型和是否有淋巴结转移患者中的差异。结果 BRCA-1基因在85例乳腺癌病理标本中，导管内癌阳性率为62．3％（5/8），浸润性导管癌阳性率为77．3％（54/70），乳腺髓样癌阳性率为71．4％（5/7），差异无统计学意义（P＞0．05）。BRCA-1基因在有淋巴转移患者中阳性率为62．9％（22/35），无淋巴结转移患者阳性率为82．5％（33/40），差异有统计学意义（ P＜0．05）。H ER-2基因在85例乳腺癌病理标本中，阳性检出率为48．2％（41/85）；有淋巴转移患者阳性率为88．6％（31/35）例，无淋巴结转移患者阳性率为25．0％（10/40），差异有统计学意义（P＜0．05）。结论 BRCA-1基因、HER-2基因与乳腺癌的发生、发展有密切的关系，对早期预防、诊断、治疗乳腺癌有重要意义。
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