孟鲁司特钠联合硫酸镁治疗老年支气管哮喘的疗效观察

摘要

Objective To explore the clinical effect of montelukast sodium combined with magnesium sulfate on elderly patents with bronchial asthma .Methods Eighty elderly patients with bronchial asthma from June 2012 to June 2013 were divided into observation group and control group randomly ,each group were 40 patients .Patients in the control group were given conventional treatment such as oxygen uptake ,anti-infection ,expectorant ,B2 receptor agonist ,glucocorticoid .The observation group was added montelukast sodium chewable tablet combined with magne-sium sulfate injection on the basis of the conventional treatment .Results The total effective rate of the observation group(95 .0% ) was significant higher than that of the control group (75 .0% ) ,the recurrence rate of the observation group (7 .5% ) was significant lower than that of the control group (30 .0% ) (P< 0 .05) .The symptoms such as gasp ,cough and chest congestion of patients in the observation group relieved significant earlier than those of the con-trol group (P<0 .05) .Before treatment ,the lung function index of the two groups had no significant difference (P>0 .05) ,Lung function index of the two groups after treatment were significantly improved ,and that in the observation group was significant better than that in the control group (P< 0 .05);There were no respiratory depression ,de-creased blood pressure and other serious adverse reactions occurred in the two groups .Conclusion The effect of montelukast sodium combined with magnesium sulfate on the elderly patients with bronchial asthma was outstand-ing ,symptom relieved quickly ,recurrence rate was low ,which was safe and reliable ,worthy of clinical promotion .%目的：探讨孟鲁司特钠联合硫酸镁治疗老年支气管哮喘的临床疗效。方法选取2012年6月至2013年6月玉林市第二人民医院收治的老年支气管哮喘患者80例，按照随机数字表法分为观察组与对照组各40例。对照组给予吸氧、抗感染、祛痰、β2受体激动剂、糖皮质激素等常规治疗，观察组在对照组的基础上加用孟鲁司特钠片和硫酸镁注射液治疗。观察并比较两组的临床疗效。结果观察组总有效率为97．1％明显高于对照组的77．1％，复发率为5．7％明显低于对照组的28．6％，差异均有统计学意义（ P＜0．05）；观察组喘息、咳嗽及胸闷等症状缓解时间均明显早于对照组，差异有统计学意义（P＜0．05）。两组患者治疗前肺功能指标比较，差异无统计学意义（P＞0．05）；治疗后肺功能指标较治疗前均明显改善，观察组改善程度优于对照组，差异有统计学意义（P＜0．05）。两组均未见呼吸抑制、血压下降等严重不良反应。结论孟鲁司特钠片联合硫酸镁注射液治疗老年支气管哮喘临床疗效显著，症状缓解快，复发率低，安全可靠，值得临床推广。