咖啡因对青光眼患者眼压影响的Meta分析

摘要

目的：评价咖啡因对青光眼患者眼压的影响。方法通过计算机检索 The Cochrane Library、PubMed、Embase、中国期刊全文数据库（CNKI）、中国科技期刊全文数据库（VIP）、万方数据库、中国生物医学文献数据库（CBM）从建库至2014年9月的相关文献，纳入口服咖啡因咖啡的随机对照试验（RCT），用RevMan5．2软件对咖啡因对青光眼患者眼压的影响进行M eta分析。结果共纳入3个研究，均为交叉试验。M eta分析结果显示，青光眼患者口服咖啡因咖啡后1 h （W M D1．58，95％ C I 0．70～2．47）及1．5 h （W M D1．46，95％ C I 1．20～1．72）眼压均有升高。结论咖啡因有升高青光眼患者眼压的作用。%Objective To evaluate the effect of caffeine on intraocular pressure in the patients with glaucoma . Methods The related literatures in the Cochrane Library ,PubMed ,Embase ,CNKI ,VIP ,Wan Fang database and CBM from the establishment to September 2014 were retrieved ,then the included randomized controlled trial(RCT) on the effect of caffeine on intraocular pressure in patients with glaucoma were performed the Meta analysis by using RevMan 5 .2 software .Results A total of 3 crossover trials were included .The results of Meta analysis showed that the intraocular pressure(IOP) was elevated at 1 h (WMD 1 .58 ,95% CI 0 .70 -2 .47) ,1 .5 h (WMD 1 .46 ,95% CI 1 .20-1 .72) after orally taking caffeine in glaucoma patients .Conclusion The caffeine has the effect for elevating IOP in the patients with glaucoma .