Dexmedetomidine as an anesthetic adjuvant to control intraocular pressure: a meta-analysis

摘要

The aim of this meta-analysis was to evaluate the effect of dexmedetomidine on intraocular pressure (IOP) and hemodynamict. Methods: There were 12 randomized clinical trials in the meta-analysis. The Primary outcomes were the Weighted Mean Difference (WMD) and the 95% Confidence Intervals (CI) of changing IOP compared dexmedetomidine with placebo. And the second outcomes were the Standardized Mean difference (SMD), the Risk Ratio (RR) and the 95% Confidence Intervals (CI). Results: Twelve trials totaling 702 patients were analyzed. In the two key point time of the anesthesia administration, the pooled estimates favored lowering effect of dexmedetomidine on IOP when compared with placebo (WMD = -4.47 mmHg, 95% CI (-6.97,-1.96), P<0.00001; and WMD = -2.13 mmHg, 95% CI (-3.51,-0.75), P=0.003, respectively). Dexmedetomidine also hastened the block onset time (WMD = -0.61 minute, 95% CI (-0.90,-0.33), P<0.0001). And there was no significant difference of hypotension between dexmedetomidine and placebo (RR = 1.12, 95% CI (0.47,2.64), P=0.80). However, for the point of the incidence of bradycardia, the use of dexmedetomidine could increase it when compared with placebo (RR = 7.50, 95% CI (1.76,31.80), P=0.006).