糖类抗原-125与人附睾蛋白4联合检测女性卵巢及子宫疾病的研究

摘要

Objective To study the value of the combined detection of HE4 and CA125 in female ovary and u‐terine diseases .Methods 52 cases of malignant ovarian tumors and 118 cases of benign ovarian tumors in our hospital from October 2010 to December 2013 were selected and detected the serum levels of CA 125 and HE4 .Contemporane‐ous 100 females of healthy physical examination were selected as the healthy control group .The ROC curve was drawn and AUC value was calculated .The values of the joint detection and single indicator detection were evaluated . Results The serum HE4 and CA125 levels had no statistically significant difference between the benign ovarian tumor group and the healthy control group (P > 0 .05) ;the serum HE4 and levels in the malignant ovarian tumor group were significantly higher than those in the healthy control group ;the positive detection rate of HE4 in the ma‐lignant ovarian tumor group was significantly higher than that of CA125 ,the difference was statistically significant (80 .8% vs .76 .9% ,P< 0 .05) ;the positive detection rate in the benign ovarian tumor group had no statistical differ ‐ence between CA125 and HE4(P> 0 .05) ;the sensitivity ,specificity ,positive predictive value and negative predictive value of the HE4 detection were significantly higher than those of CA 125 ,which of the combined detection were higher than those of the single detection ,but which had no statistical difference compared with HE4(P > 0 .05) and had statistical difference compared with HE4(P< 0 .05) .Conclusion The combined detection of HE4 and CA125 can increase the detection sensitivity in female ovarian and uterine diseases and is suitable for the evaluation of women ′s health check‐up .%目的：探讨糖类抗原‐125（CA125）与人附睾蛋白4（HE4）联合检测女性卵巢及子宫疾病的价值。方法选择2010年10月至2013年12月在该院就诊的52例恶性卵巢肿瘤和118例良性卵巢肿瘤患者，检测患者的血清 CA125与 HE4水平。另选同期在该院进行健康体检的健康女性100例作为健康对照组，并绘制 ROC 曲线，计算 AUC 值，比较联合检测与单项检测的评价指标。结果良性卵巢肿瘤组血清 HE4和 CA125与健康对照组差异无统计学意义（P＞0．05），而恶性卵巢肿瘤组血清 HE4和 CA125水平较健康对照组明显升高；恶性卵巢肿瘤组HE4检测阳性率（80．8％）明显高于 CA125的阳性率（76．9％），差异有统计学意义（P ＜0．05）；良性卵巢肿瘤组HE4检测阳性率与 CA125差异无统计学意义（P＞0．05）；HE4检测的灵敏度、特异性、阳性预测值、阴性预测值均明显高于 CA125，联合检测的灵敏度、特异性、阳性预测值高于单项检测，与 HE4比较差异无统计学意义（P＞0．05），与 CA125比较差异有统计学意义（P＜0．05），联合检测的灵敏度、AUC 明显高于单项检测。结论 CA125与 HE4联合检测女性卵巢及子宫疾病可提高检测的灵敏度，适用于女性健康体检的评估。