血清人附睾蛋白 4 和卵巢癌风险预测模型指数诊断卵巢癌的最佳切割值

摘要

目的 探讨血清人附睾蛋白4(HE4)及卵巢癌风险预测模型(ROMA)诊断卵巢癌的最佳切割值.方法 检测该院64例卵巢癌患者和47例卵巢良性肿瘤患者的糖类抗原125(CA125)和 HE4水平 ,并计算ROMA ,绘制受试者工作(ROC )曲线 ,获得新的切割值 ,并与试剂厂商(罗氏)提供的切割值进行多指标比较.结果 (1 ) HE4新的切割值为90 .29 pmol/L ,诊断敏感度为89 .1% ,特异度为88 .9% ,两者之和为1 .78;罗氏提供的切割值为140 pmol/L ,敏感度70 .3% ,特异度95 .6% ,两者之和较低(1 .659).(2)ROMA在绝经前新的切割值为28 .0% ,敏感度92 .3% ,特异度96 .7% ,两者之和为1 .89 ;罗氏提供的切割值为11 .4% ,敏感度92 .3% ,特异度63 .3% ,两者之和较低(1 .556 ).在绝经后新的切割值为57 .0% ,敏感度88 .2% ,特异度100 .0% ,两者之和为1 .882 ,罗氏提供的切割值为29 .9% ,敏感度98 .0% ,特异度60 .0% ,两者之和较低(1 .58 ).结论 该实验室的最佳切割值 :H E4为90 .29 pmol/L ,ROMA绝经前后分别为28 .0% 和57 .0% ;罗氏提供的HE4偏高 ,ROMA偏低.%Objective To evaluate the best cut-off of serum human epididymis protein 4 (HE4) and ovarian cancer risk prediction model (ROMA) in the diagnosis of ovarian cancer .Methods Review of CA125 and HE4 levels in 64 patients with ovarian cancer and 47 cases of benign ovarian tumor analysis of Jiangsu Province ,Nantong City ar-ea ,and calculated the ROMA drawing ROC curves ,obtained the new value ,and with the reagent manufacturers (Roche) provides the cutting value of multi index comparative analysis .Results (1)HE4 new cut-off is 90 .29 pmol/L ,the diagnostic sensitivity was 89 .1% ,specificity was 88 .9% ,and the sum of them was 1 .78;Roche provided cut-off was 140 pmol/L ,the sensitivity was 70 .3% ,specificity was 95 .6% ,and their sum was lower (1 .659);(2) Prem-enopausal ROMA new cut-off was 28 .0% ,the sensitivity was 92 .3% ,specificity was 96 .7% ,and the sum of them w as 1 .89 ,Roche provided cut-off w as 11 .4% ,the sensitivity w as 92 .3% ,specificity w as 63 .3% ,and their sum w as lower (1 .556);ROMA in postmenopausal women with a new cut-off was 57 .0% ,the sensitivity was 88 .2% ,speci-ficity was 100 .0% ,and the sum of them was 1 .882 ,Roche provided cut-off after menopause was 29 .9% ,the sensitiv-ity was 98 .0% ,specificity was 60 .0% ,and their sum was lower (1 .58) .Conclusion On the local area ,the cut-off values :HE4 90 .29 pmol/L ,ROMA before and after menopause are respectively 28 .0% ,57 .0% ;the cut-off of HE4 provided by Roche is high ,while the value of ROMA is low .