湖北汉族RhD阴性住院患者Rh表型分布特征研究

摘要

Objective To investigate the diversity of RhD negative phenotype among hospitalized Hubei Han Chinese patients .Methods RhD negative was identified by anti‐D with three batch numbers ,and erythrocyte Rh phe‐notype in RhD negative hospitalized patients was detected by Rh typing reagent .Results In 612 RhD negative hospi‐talized patients ,Female A and O blood group number was more than male .7 phenotypes were found in this study group ,and the phenotype frequency of ccee ,Ccee ,CCee ,ccEe ,CcEe ,ccEE and CcEE was 62 .1% ,27 .6% ,6 .5% , 1 .6% ,1 .5% ,0 .3% and 0 .3% ,respectively .Conclusion Female A and O blood group individuals were more than male among hospitalized Hubei Han Chinese RhD negative patients ,the phenotype frequency of ccee was highest , ccEE and CcEE was lowest ,which was importantly significant for clinical blood transfusion safety of RhD negative patients .%目的：探讨湖北地区汉族RhD阴性住院患者Rh表型的分布特征。方法采用3个不同批号的抗‐D血清对筛查的 RhD 阴性患者标本进行确认，612例确认 RhD 阴性患者标本用 Rh 分型试剂检测 Rh 表型。结果612例 RhD 阴性患者中，A 型和 O 型女性人群显著多于男性，共检出7种 Rh 表型，其中 ccee 的表型频率为62．1％，Ccee 的表型频率为27．6％，CCee 的表型频率为6．5％，ccEe 的表型频率为1．6％，CcEe 的表型频率为1．5％，ccEE 和 CcEE 的表型频率均为0．3％。结论湖北地区汉族 RhD 阴性住院患者，A 型和 O 型女性多于男性，Rh 表型频率以 ccee 表型为最高，ccEE 和 CcEE 表型为最低，为临床 RhD 阴性患者安全输血具有重要的临床意义。