肿瘤标志物CA72-4对胃癌患者预后影响的系统评价

摘要

目的 系统评价肿瘤标志物糖类抗原(CA)72-4对胃癌患者的预后影响.方法 使用计算机系统地检索PubMed和Embase数据库关于CA72-4和胃癌预后的文献,文献检索日期截止至2014年7月.除了进行总的Meta分析,同时还进行合适的敏感性分析和亚组分析.结果 本研究共纳入符合纳入标准的文章13篇,共计4 604例胃癌患者.与CA72-4正常的胃癌患者比较,CA72-4阳性患者的总生存率(HR=1.49,95%CI 1.25~1.77,P<0.01)和无病生存率差(HR=2.26,95%CI 1.54~3.30),差异有统计学意义(P<0.01).结论 Meta分析提示胃癌患者肿瘤标志物CA72-4水平与预后相关,可作为重要的预后影响因素.%Objective The aim of our meta-analysis is to assess the prognostic value of carbohydrate antigen 72-4(CA72-4) in patients with gastric cancer.Methods PubMed,Embase,and the references in relevant studies were systematically searched(up to July,2014).Besides overall analysis,subgroup and sensitivity analyses were also performed.Results Thirteen eligible studies were analyzed,containing 4 604 patients with gastric cancer.CA72-4 level was significantly inversely associated with the overall survival(OS,HR=1.49,95%CI 1.25-1.77,P<0.001) and disease-free survival(DFS,HR=2.26,95%CI 1.54-3.30,P<0.01).Conclusion Our meta-analysis indicates that CA72-4 level is inversely associated with the prognosis for gastric cancer and may play an important prognostic factor for patients with gastric cancer.