湖北地区14~96岁健康人群sdLDL-C生物水平参考区间的建立

摘要

Objective To conduct the survey and statistics on the distribution of small dense low density lipoprotein cholesterol(sdLDL-C) among the healthy population aged 14-96 years old in Hubei area for establishing the reference intervals of sdLDL-C biological levels.Methods A total of 1 217 healthy people in this area,including 602 males and 615 females,were included.The sdLDL-C level in this population was detected for conducting statistics.The detection results were compared with the reference intervals offered by the reagent kit.Finally the sdLDL-C reference intervals for local laboratory were established.Results The distribution situation of sdLDL-C in the healthy population of Hubei area was as follows.The female group 1,M=0.460 0 mmol/L;group 2,M=0.530 0 mmol/L;group 3,M=0.600 0 mmol/L;group 4,M=0.600 0 mmol/L;group 5,M=0.715 0 mmol/L,male group 6,M=0.550 0 mmol/L,group 7,M=0.610 0 mmol/L,group 8,M=0.580 0 mmol/L,group 9,M=0.630 0 mmol/L,group 10,M=0.640 0 mmol/L;the sdLDL-C level in female people aged below 50 years old was significantly higher than that in the same age of female(P=0.01).The sdLDL-C level in people aged over 50 year old had no sexual difference,but the sdLDL-C increment amplitude in females aged over 60 years old was higher than that in the same age of males.The reference intervals of sdLDL-C biological levels were female aged 15-29 years old,0.310 0-0.878 8 mmol/L;>29-39 years old,0.341 0-0.930 0 mmol/L,>39-59 years old,0.350 0-1.040 0 mmol/L,60-96 years old,0.374 8-1.175 2 mmol/L;male,14-32 years old,0.323 5-0.916 0 mmol/L,>32-96 years old,0.370 0-1.210 0 mmol/L.Conclusion The distribution situation of sdLDL-C level in the population of Hubei area has difference from the reference range offered by reagent kit,and these established reference intervals can provide a basis for the laboratories in Hubei area.%目的 调查统计湖北地区14~96岁健康人群血清小而密低密度脂蛋白胆固醇(sdLDL-C)水平分布,建立生物水平参考区间.方法 选取湖北地区健康人群1 217例,女615例,男602例.检测统计上述人群血清sdLDL-C水平,与检测试剂盒提供的参考区间对比,根据sdLDL-C在该地区人群的分布情况,建立实验室参考区间.结果 湖北地区14~96岁健康人群sdLDL-C水平分布情况如下.女1组M=0.460 0 mmol/L,2组M=0.530 0 mmol/L,3、4组M=0.600 0 mmol/L,5组M=0.715 0 mmol/L;男6组M=0.550 0 mmol/L,7组M=0.610 0 mmol/L,8组M=0.580 0 mmol/L,9组M=0.630 0 mmol/L,10组M=0.640 0 mmol/L;男性小于50岁人群sdLDL-C水平显著高于同年龄段女性(P=0.01).年龄大于50岁人群sdLDL-C水平无性别差异,但女性大于60岁人群sdLDL-C水平增幅比同龄男性高.该地区sdLDL-C生物水平参考区间如下:女15~29岁为0.310 0~0.878 8 mmol/L,>29~39岁为0.341 0~0.930 0 mmol/L,>39~59岁为0.350 0~1.040 0 mmol/L,>59~96岁为0.374 8~1.175 2 mmol/L;男14~32岁为0.323 5~0.916 0 mmol/L,>32~96岁为0.370 0~1.210 0 mmol/L.结论 湖北地区人群sdLDL-C水平分布情况与试剂参考区间存在差异,该参考区间的建立可为湖北地区实验室提供参考.